Evidence map›Paper›PMID 28471243›Full record

ArticleBrain injury2017

Utility of providing a concussion definition in the assessment of concussion history in former NFL players.

Michael L Alosco, Johnny Jarnagin, Yorghos Tripodis, Brett Martin, Christine Chaisson, Christine M Baugh, Alcy Torres, Christopher J Nowinski, Robert C Cantu, Robert A Stern

Abstract read
In one paragraph

Article in Brain injury, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. White matter hyperintensities in former American football players.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Associations between adverse childhood experiences and acquired brain injury, including traumatic brain injuries, among adults: 2014 BRFSS North Carolina.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2019
    Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael L Aloscoa Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine , Boston , MA , USA.
Johnny Jarnagina Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine , Boston , MA , USA.
Yorghos Tripodisc Department of Biostatistics , Boston University School of Public Health , Boston , MA , USA.
Brett Martina Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine , Boston , MA , USA.
Christine Chaissona Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine , Boston , MA , USA.
Christine M Baugha Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine , Boston , MA , USA.
Alcy Torresf Pediatric Neurology , Boston University School of Medicine , Boston , MA , USA.
Christopher J Nowinskih Concussion Legacy Foundation , Waltham , MA , USA.
Robert C Cantua Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine , Boston , MA , USA.
Robert A Sterna Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine , Boston , MA , USA.

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
Health Policy Training Program: Promoting Outcomes, Quality, Equity and Diffusion of AdvancesT32MH019733 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Benjamin Le Cook, Haiden A Huskamp · 1993 to 2026
$7.0M
Chronic Traumatic Encephalopathy: Clinical Presentation and BiomarkersR01NS078337 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STERN, ROBERT A · 2011 to 2013
$2.0M
Chronic Traumatic Encephalopathy: Clinical Presentation and BiomarkersR56NS078337 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STERN, ROBERT A · 2014 to 2014
$786k
Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic EncephalopathyF32NS096803 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ALOSCO, MICHAEL · 2016 to 2017
$118k
NCATS NIH HHS UL1 TR001430NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG019610NIMH NIH HHS T32 MH019733NINDS NIH HHS F32 NS096803NINDS NIH HHS R01 NS078337NINDS NIH HHS R56 NS078337NINDS NIH HHS U01 NS093334
6 · The paper itself

Abstract

objectiveFormer National Football League (NFL) players' working knowledge of concussion has not yet been evaluated, despite this population being a major clinical research target due to the association between repetitive head impacts (RHI) and long-term clinical impairments. This study examined former NFL players' understanding of the current concussion definition, and the association between number of concussions with clinical function.

methods95 former NFL players (mean age = 55.29; mean NFL year = 8.10) self-reported number of concussions before being provided with a concussion definition and after being read a modern definition of concussion. Subjects reported number of concussions with loss of consciousness (LOC). Principal Component Analysis of a battery of tests generated behaviour/mood, psychomotor speed/executive function, and verbal and visual memory factor scores.

resultsPost-definition number of concussions (median = 50) was five times the pre-definition (median = 10; p < 0.001). Greater pre- (p = 0.019) and post-definition concussions (p = 0.036) correlated with worse behaviour/mood scores, after controlling for years of football played, with specific effects for depressive symptoms and impulsivity. LOC did not account for variance beyond number of concussions.

conclusionsPractitioners and clinical researchers should provide a definition of concussion in the assessment of concussion history in former football players to facilitate accuracy and standardization.

Indexed as

AgedBrain ConcussionCognition DisordersConsciousness DisordersFootballHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPrincipal Component AnalysisTrauma Severity IndicesAmerican footballconcussion knowledgedepressionimpulsivitymild traumatic brain injury

Identifiers

PMID28471243
PMCPMC6157273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.