ReviewThe British journal of radiology2017
Low radiation dose in computed tomography: the role of iodine.
Review in The British journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Low tube voltage prospectively ECG-triggered coronary CT angiography: a systematic review of image quality and radiation dose.The British journal of radiology · 2018Pooled it
- Evaluation of image quality on low contrast media with deep learning image reconstruction algorithm in prospective ECG-triggering coronary CT angiography.The international journal of cardiovascular imaging · 2024Trial
- Ladder-Like Low Iodine Delivery Rate Injection Protocols Based on BMI at 70 KV by Automated Tube Voltage Selection in Coronary CTA.Contrast media & molecular imaging · 2022Trial
- CT attenuation of liver metastases before targeted therapy is a prognostic factor of overall survival in colorectal cancer patients. Results from the randomised, open-label FIRE-3/AIO KRK0306 trial.European radiology · 2018Trial
- Where Does the Signal Go? Technical Challenges of CT Perfusion in Lacunar and Infratentorial Stroke.Tomography (Ann Arbor, Mich.) · 2026Review
- Single-slice ct body-weight prediction with image and metadata fusion: a multi-model comparison.Radiological physics and technology · 2026Article
- Contemporary strategies for dose optimization in pediatric congenital heart disease CT: size-specific acquisition and detector-level advances.Radiological physics and technology · 2026Review
- Effectiveness of low-tube current for reducing radiation dose in cerebral computed tomography perfusion.Archives of medical science : AMS · 2026Article
- High-Resolution 3-Dimensional Micro-CT Imaging of Intervertebral Discs Using a Novel Contrast Agent.JOR spine · 2025Article
- Double low-dose abdominopelvic CT for acute appendicitis: early exploratory analysis on image quality and diagnostic performance.Abdominal radiology (New York) · 2025Article
- Contrast media and radiation dose optimization with task-based automatic keV selection: a proof-of-concept study with photon-counting detector CT.European radiology · 2025Article
- Innovation and Optimization of Contrast Media Administration in Computed Tomography.Korean journal of radiology · 2025Article
- Low Dose Contrast Enhanced CT Thorax Protocol: Comparison of Low Kilovoltage, Low Contrast Volume Using Iterative Reconstruction Technique with Standard Protocol.Ethiopian journal of health sciences · 2025Article
- Feasibility of Low-Dose and Low-Contrast Media Volume Approach in Computed Tomography Cardiovascular Imaging Reconstructed with Model-Based Algorithm.Tomography (Ann Arbor, Mich.) · 2024Article
- Computed tomography image quality in patients with primary hepatocellular carcinoma: intraindividual comparison of contrast agent concentrations.Frontiers in medicine · 2024Article
- Evaluating the Necessity and Radiation Risk of Brain CT Scans Requested by the Trauma Emergency Department.Journal of biomedical physics & engineering · 2023Article
- A comparison of the use of contrast media with different iodine concentrations for enhanced computed tomography.Frontiers in physiology · 2023Article
- The effect of computed tomography parameters on sarcopenia and myosteatosis assessment: a scoping review.Journal of cachexia, sarcopenia and muscle · 2022Article
- Evaluating the Image Quality of Neck Structures Scanned on Chest CT with Low-Concentration-Iodine Contrast Media.Tomography (Ann Arbor, Mich.) · 2022Article
- Recommendations in pre-procedural imaging assessment for TAVI intervention: SIC-SIRM position paper part 2 (CT and MR angiography, standard medical reporting, future perspectives).La Radiologia medica · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent approaches to reducing radiation exposure during CT examinations typically utilize automated dose modulation strategies on the basis of lower tube voltage combined with iterative reconstruction and other dose-saving techniques. Less clearly appreciated is the potentially substantial role that iodinated contrast media (CM) can play in low-radiation-dose CT examinations. Herein we discuss the role of iodinated CM in low-radiation-dose examinations and describe approaches for the optimization of CM administration protocols to further reduce radiation dose and/or CM dose while maintaining image quality for accurate diagnosis. Similar to the higher iodine attenuation obtained at low-tube-voltage settings, high-iodine-signal protocols may permit radiation dose reduction by permitting a lowering of mAs while maintaining the signal-to-noise ratio. This is particularly feasible in first pass examinations where high iodine signal can be achieved by injecting iodine more rapidly. The combination of low kV and IR can also be used to reduce the iodine dose. Here, in optimum contrast injection protocols, the volume of CM administered rather than the iodine concentration should be reduced, since with high-iodine-concentration CM further reductions of iodine dose are achievable for modern first pass examinations. Moreover, higher concentrations of CM more readily allow reductions of both flow rate and volume, thereby improving the tolerability of contrast administration.
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