ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017
In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines.
Open access · bronzeAbstract read
In one paragraph
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Metabolic adaptations rewire CD4Nature immunology · 2026Article
- Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tetrahydrobiopterin enhances regulatory T- and mast cell proliferation and alters cytokines expression in a murine heart transplant model.Scientific reports · 2025Article
- Aryl hydrocarbon receptor: current perspectives on key signaling partners and immunoregulatory role in inflammatory diseases.Frontiers in immunology · 2024Review
- Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives.Cells · 2022Review
- Clinical development of metabolic inhibitors for oncology.The Journal of clinical investigation · 2022Review
- Emerging translational strategies and challenges for enhancing regulatory T cell therapy for graft-versus-host disease.Frontiers in immunology · 2022Review
- Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS).Frontiers in immunology · 2022Article
- Correlation of Tryptophan Metabolic Pathway with Immune Activation and Chemosensitivity in Patients with Lung Adenocarcinoma.Journal of oncology · 2022Article
- Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells.Molecular medicine reports · 2021Article
- Therapeutic Liposomal Vaccines for Dendritic Cell Activation or Tolerance.Frontiers in immunology · 2021Review
- Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity.JCI insight · 2020Article
- IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer.Blood advances · 2020Article
- Distinct Regulatory and Effector T Cell Metabolic Demands during Graft-Versus-Host Disease.Trends in immunology · 2020Review
- Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits.Psychoneuroendocrinology · 2019Article
- Therapeutic use of regulatory T cells for graft-versus-host disease.British journal of haematology · 2019Review
- Methods to manufacture regulatory T cells for cell therapy.Clinical and experimental immunology · 2019Review
- Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.Nature reviews. Drug discovery · 2019Review
- The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation.Nature communications · 2019Article
- Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis.Frontiers in immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 8 institutions in 1 country.
K L HippenDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN.
R S O'ConnorDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
A M LemireDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN.
A SahaDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN.
E A HanseDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
N C TennisDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN.
S C MerkelDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN.
A KelekarDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
J L RileyAbramson Family Cancer Center Research Institute, University of Pennsylvania, Philadelphia, PA.
B L LevineAbramson Family Cancer Center Research Institute, University of Pennsylvania, Philadelphia, PA.
C H JuneAbramson Family Cancer Center Research Institute, University of Pennsylvania, Philadelphia, PA.
L A TurkaCenter for Transplantation Sciences and Immune Tolerance Network, Massachusetts General Hospital, Boston, MA.
L S KeanBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, University of Washington, Seattle, WA.
M L MacMillanDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN.
J S MillerDivision of Hematology/Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN.
J E WagnerDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN.
D H MunnMedical College of Georgia, Immunotherapy Center, Augusta, GA.
B R BlazarDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN.
Masonic Cancer CenterUniversity of Minnesota · USUniversity of Minnesota Medical Center · USUniversity of Pennsylvania · USAugusta University · USFred Hutch Cancer Center · USImmune Tolerance Network · USUPMC Hillman Cancer Center · US
Funding
Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4MTransplant Tolerance in Non-Human PrimatesU19AI051731 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI LARSEN, CHRISTIAN P. · 2002 to 2022
$54.1MTrial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Mark J Osborn · 1995 to 2026
$48.2MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 2003 to 2023
$42.5MTherapeutic Potential of Adaptive NK Cells in Cancer and TransplantationP01CA111412 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MILLER, JEFFREY S. · 2005 to 2025
$38.2MUniversity of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0MProject 3: Humoral Targets and B Cell Biology in Chronic Graft-vs.-Host DiseaseP01CA142106 · NCI · DANA-FARBER CANCER INST · PI CUTLER, COREY S · 2009 to 2019
$17.5MObesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BERNLOHR, DAVID A · 1995 to 2015
$17.0MNovel Biologic Therapies for GVHDR01HL095791 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2010 to 2025
$13.3MEnhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7MReprogramming the TME for immunogenic antigen-presentationR01CA103320 · NCI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MUNN, DAVID H. · 2003 to 2024
$6.0MT-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4MNCATS NIH HHS UL1 TR000114NCI NIH HHS F31 CA177119NCI NIH HHS F32 CA067493NCI NIH HHS P01 CA065493NCI NIH HHS P01 CA111412NCI NIH HHS P01 CA142106NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA096651NCI NIH HHS R01 CA103320NCI NIH HHS R01 CA157971NHLBI NIH HHS N01 HB037164NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL095791NHLBI NIH HHS R01 HL114512NHLBI NIH HHS R01 HL118979NIAID NIH HHS P01 AI056299NIAID NIH HHS R37 AI034495NIAID NIH HHS U19 AI051731NIDDK NIH HHS P30 DK050456
Abstract
Thymic regulatory T cells (tTregs) and induced regulatory T cells (iTregs) suppress murine acute graft-versus-host disease (GVHD). Previously, we demonstrated that the plasmacytoid dendritic cell indoleamine 2,3-dioxygenase (IDO) fosters the in vitro development of human iTregs via tryptophan depletion and kynurenine (Kyn) metabolites. We now show that stimulation of naïve CD4
Indexed as
Bone Marrow TransplantationAnimalsCells, CulturedGraft vs Host DiseaseHumansImmune ToleranceIn Vitro TechniquesKynurenineMiceSurvival RateT-Lymphocytes, RegulatoryTryptophanKynurenineTryptophanbasic (laboratory) research/sciencebone marrow/hematopoietic stem cell transplantationgraft-versus-host disease (GVHD)immune regulationimmunosuppression/immune modulationT cell biologytolerance: clinicaltranslational research/sciencexenotransplantation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.