Evidence map›Paper›PMID 28470583›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2017

Interaction Effects between HIV and Aging on Selective Neurocognitive Impairment.

Yingying Ding, Haijiang Lin, Weiwei Shen, Qionghai Wu, Meiyang Gao, Na He

Abstract read
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In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  17. Cognitive Trajectory Phenotypes in Human Immunodeficiency Virus-Infected Patients.Journal of acquired immune deficiency syndromes (1999) · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yingying DingDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China.
Haijiang LinDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China.
Weiwei ShenTaizhou City Center for Disease Control and Prevention, Taizhou City, Zhejiang Province, China.
Qionghai WuTaizhou City Center for Disease Control and Prevention, Taizhou City, Zhejiang Province, China.
Meiyang GaoDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China.
Na HeDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China. nhe@shmu.edu.cn.
Fudan University · CN

Funding

Fourth Round of Three-Year Public Health Action Plan of Shanghai, China 15GWZK0101Fourth Round of Three-Year Public Health Action Plan of Shanghai, China GWTD2015S05Junior Faculty Award of Fudan University JJF201016National Natural Science Foundation of China 81373062National Natural Science Foundation of China 81402725
6 · The paper itself

Abstract

HIV infection and aging are each associated with neurocognitive impairment (NCI). This study examined the combined effects of HIV infection and aging on NCI. We performed a cross-sectional survey among 345 HIV-infected and 345 HIV-uninfected participants aged at least 40 years. The International HIV Dementia Scale (IHDS) and Chinese version of Mini-mental State Examination (MMSE) were administered to screen for NCI. HIV-infected individuals had higher prevalence of NCI than uninfected individuals (46.7% vs 15.1% for IHDS using cut-off of ≤ 10; 17.1% vs 2.6% for MMSE). Significant main effects of HIV and age were observed on IHDS and MMSE composite scores and all domains except for HIV on attention and calculation. Significant interaction effects between HIV and age were observed on motor speed, orientation, registration and recall, and mainly attributed to the inferior performance of HIV-infected patients aged over 60 years. Among HIV-infected individuals, in multivariable logistic models, older age, depressive symptoms and history of nevirapine treatment were associated with NCI using both IHDS and MMSE, whereas lower education current smoker and current CD4 ≥ 800 cells/μL were associated only with NCI using IHDS, and hypertension was associated only with NCI using MMSE. Findings suggest that HIV and older age may confer interactive effects on cognitive function in several domains with older HIV-infected adults experiencing greater NCI, which requires further longitudinal investigation. Furthermore, HIV early diagnosis and treatment may prevent or reverse NCI, but extra attention should be given to adverse effects including metabolic changes associated with long-term treatment.

Indexed as

AdultAgedAged, 80 and overAgingAIDS Dementia ComplexCognition DisordersCross-Sectional StudiesFemaleHIV InfectionsHumansMaleMiddle AgedNeuropsychological TestsPrevalenceAccelerated agingCD4 countChinaHIVNeurocognitive impairmentOlder age

Identifiers

PMID28470583
OpenAlexW2610734785

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.