ArticlePsychopharmacology2017
Predicting relapse with individual residual symptoms in major depressive disorder: a reanalysis of the STAR*D data.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Residual Fatigue in Unipolar and Bipolar Depression: A Systematic Review.Neuropsychopharmacology reports · 2025Pooled it
- Residual insomnia in major depressive disorder: a systematic review.Frontiers in psychiatry · 2023Pooled it
- A Systematic Review and Individual Patient Data Network Analysis of the Residual Symptom Structure Following Cognitive-Behavioral Therapy and Escitalopram, Mirtazapine and Venlafaxine for Depression.Frontiers in psychiatry · 2022Pooled it
- Digital CBT-I in Comorbid Insomnia and Depression: Clinical Outcomes From a Pragmatic Randomized Controlled Trial.Depression and anxiety · 2025Trial
- Predictors of response to pharmacotherapy in children and adolescents with psychiatric disorders: A combined post hoc analysis of four clinical trial data.Neuropsychopharmacology reports · 2022Trial
- Measuring psychomotor agitation via hand tremor in remitted major depressive disorder.Journal of psychiatric research · 2026Article
- Network analysis of intimate partner violence and depression-anxiety symptoms in Chinese transgender women.BMC public health · 2026Article
- Anxiety-depression symptom networks across emotion regulation profiles in Chinese nurses: a latent profile and network analysis.BMC nursing · 2026Article
- Within-person associations of daily activity to sleep actigraphy following trauma: Explicating a novel index of risk for major depressive disorder and posttraumatic stress disorder.Journal of psychopathology and clinical science · 2025Article
- Differences in the 24-h autonomic nervous activity of outpatients with major depressive disorder with or without hypersomnia: An exploratory observational study.BioPsychoSocial medicine · 2025Article
- The Association between Intranasal Esketamine and Treatment-emergent Insomnia in the Treatment of Treatment-resistant Major Depression: A Meta-analysis.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Exploring the Inter-relationship of depressive and anxiety symptoms associated with suicidal ideation among migrant industrial workers in shenzhen: a network analysis approach.BMC public health · 2025Article
- The Association Between Childhood Trauma and Selective Serotonin Reuptake Inhibitor Treatment Outcomes in Adult Patients With Major Depressive Disorder.Psychiatry investigation · 2025Article
- Trends in hypnotic drug use in depression 2007-2017: A Swedish population-based study.Journal of sleep research · 2025Article
- Predictors of Changes in Depressive Symptoms with Major Depressive Disorder - A Naturalistic 6-month Follow-up Study.Neuropsychiatric disease and treatment · 2025Article
- The Search for Consistency in Residual Symptoms in Major Depressive Disorder: A Narrative Review.Journal of personalized medicine · 2024Review
- Risk of Comorbid Insomnia Disorder Associated with Major Depression in Apneic Patients: A Cross-Sectional Study.Clocks & sleep · 2024Article
- Network analysis of depression and anxiety symptoms and their associations with mobile phone addiction among Chinese medical students during the late stage of the COVID-19 pandemic.SSM - population health · 2024Article
- Impacts of sleep disturbance and work-related life stress on depression among Japanese and Chinese workers.PloS one · 2024Article
- Psychometric evaluation and linking of the PHQ-9, QIDS-C, and VQIDS-C in a real-world population with major depressive disorder.Neuropsychiatric disease and treatment · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResidual symptoms are detrimental to prognosis in major depressive disorder (MDD); however, little is known about the contribution of each residual symptom in predicting outcomes. The objective of this analysis was to identify which individual symptoms, based on self-report and clinician interview, could predict subsequent relapse.
methodsThe data of 1133 outpatients with nonpsychotic MDD who entered a 12-month naturalistic follow-up phase after achieving remission with level 1 treatment (i.e., citalopram for up to 14 weeks) and had at least one post-baseline contact in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were analyzed. Specific residual symptoms in the 16-item Quick Inventory of Depressive Symptomatology, self-report (QIDS-SR
resultsThe following three QIDS-SR LIMITATIONS: The original trial was not designed to evaluate the issue addressed herein. Individual symptoms may be associated with each other and functional status was not addressed.
conclusionsSome residual symptoms, including restlessness, insomnia, and weight change, may help better identify patients with MDD vulnerable to relapse. Contribution of individual residual symptoms to subsequent relapse was similar between self-report and clinician-rated symptoms.
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