Evidence map›Paper›PMID 28470387›Full record

ArticlePediatric radiology2017

Comparison of CT enterography and MR enterography imaging features of active Crohn disease in children and adolescents.

Heather I Gale, Steven M Sharatz, Mayureewan Taphey, William F Bradley, Katherine Nimkin, Michael S Gee

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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  3. [European journal of nuclear medicine and molecular imaging · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heather I GaleDepartment of Diagnostic Imaging, Rhode Island Hospital/Hasbro Children's Children's Hospital/Women and Infants Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy St., Providence, RI, 02903, USA. heather_gale@brown.edu.
Steven M SharatzDivision of Pediatric Imaging, Department of Radiology, Harvard Medical School, MassGeneral Hospital for Children, Boston, MA, USA.
Mayureewan TapheyBumrungrad International Hospital, Wattana, Bangkok, Thailand.
William F BradleyCambridge Mobile Telematics, Cambridge, MA, USA.
Katherine NimkinDivision of Pediatric Imaging, Department of Radiology, Harvard Medical School, MassGeneral Hospital for Children, Boston, MA, USA.
Michael S GeeDivision of Pediatric Imaging, Department of Radiology, Harvard Medical School, MassGeneral Hospital for Children, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessment for active Crohn disease by CT enterography and MR enterography relies on identifying mural and perienteric imaging features.

objectiveTo evaluate the performance of established imaging features of active Crohn disease in children and adolescents on CT and MR enterography compared with histological reference. MATERIALS AND

methodsWe included patients ages 18 years and younger who underwent either CT or MR enterography from 2007 to 2014 and had endoscopic biopsy within 28 days of imaging. Two pediatric radiologists blinded to the histological results reviewed imaging studies and scored the bowel for the presence or absence of mural features (wall thickening >3 mm, mural hyperenhancement) and perienteric features (mesenteric hypervascularity, edema, fibrofatty proliferation and lymphadenopathy) of active disease. We performed univariate analysis and multivariate logistic regression to compare imaging features with histological reference.

resultsWe evaluated 452 bowel segments (135 from CT enterography, 317 from MR enterography) from 84 patients. Mural imaging features had the highest association with active inflammation both for MR enterography (wall thickening had 80% accuracy, 69% sensitivity and 91% specificity; mural hyperenhancement had 78%, 53% and 96%, respectively) and CT enterography (wall thickening had 84% accuracy, 72% sensitivity and 91% specificity; mural hyperenhancement had 76%, 51% and 91%, respectively), with perienteric imaging features performing significantly worse on MR enterography relative to CT enterography (P < 0.001).

conclusionMural features are predictors of active inflammation for both CT and MR enterography, while perienteric features can be distinguished better on CT enterography compared with MR enterography. This likely reflects the increased conspicuity of the mesentery on CT enterography and suggests that mural features are the most reliable imaging features of active Crohn disease in children and adolescents.

Indexed as

AdolescentBiopsyChildCrohn DiseaseFemaleHumansMagnetic Resonance ImagingMaleSensitivity and SpecificityTomography, X-Ray ComputedChildrenComputed tomography enterographyCrohn diseaseInflammatory bowel diseaseMagnetic resonance enterography

Identifiers

PMID28470387

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