ArticleMolecular and cellular biology1988
Control of yeast gene expression by transposable elements: maximum expression requires a functional Ty activator sequence and a defective Ty promoter.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The effect of hybridization on transposable element accumulation in an undomesticated fungal species.eLife · 2020Article
- Article
- Local definition of Ty1 target preference by long terminal repeats and clustered tRNA genes.Genome research · 2004Article
- Article
- Binding of a cell-type-specific RNA splicing factor to its target regulatory sequence.Molecular and cellular biology · 1995Article
- Transposition of the yeast retroviruslike element Ty3 is dependent on the cell cycle.Molecular and cellular biology · 1994Article
- Site-selected insertion of the transposon Tc1 into a Caenorhabditis elegans myosin light chain gene.Molecular and cellular biology · 1993Article
- MEI4, a meiosis-specific yeast gene required for chromosome synapsis.Molecular and cellular biology · 1992Article
- The Saccharomyces cerevisiae SPT14 gene is essential for normal expression of the yeast transposon, Ty, as well as for expression of the HIS4 gene and several genes in the mating pathway.Molecular & general genetics : MGG · 1991Article
- The SNF2, SNF5 and SNF6 genes are required for Ty transcription in Saccharomyces cerevisiae.Genetics · 1991Article
- TEC1, a gene involved in the activation of Ty1 and Ty1-mediated gene expression in Saccharomyces cerevisiae: cloning and molecular analysis.Molecular and cellular biology · 1990Article
- MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis.Molecular and cellular biology · 1990Article
- Ty RNA levels determine the spectrum of retrotransposition events that activate gene expression in Saccharomyces cerevisiae.Molecular & general genetics : MGG · 1990Article
- The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription.Molecular and cellular biology · 1989Article
- Enhancer and silencerlike sites within the transcribed portion of a Ty2 transposable element of Saccharomyces cerevisiae.Molecular and cellular biology · 1989Article
- A region internal to the coding sequences is essential for transcription of the yeast Ty-D15 element.Molecular and cellular biology · 1989Article
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Authors and funding
2 authors.
Funding
Abstract
Integration of a transposable element adjacent to a gene frequently results in an alteration in expression of the nearby gene. The purpose of our experiments was to identify cis-acting sequences within a yeast transposon (Ty) that are important for expression of the adjacent gene. The role of these sequences in Ty transcription was also analyzed in order to examine the relationship between Ty and adjacent gene expression. Three naturally occurring Ty elements located at the HIS4 locus were examined. These Ty elements differed by multiple sequence changes and had different effects on HIS4 expression. To determine which sequences were important to Ty and HIS4 expression, Ty::lacZ and Ty::HIS4::lacZ fusion genes were constructed and analyzed. Results of these experiments indicated that a sequence element is present in the Ty epsilon region that is necessary for HIS4 expression but which has only a modest effect on Ty transcription. Additionally, a mutation in the Ty promoter region decreased Ty transcription and increased HIS4 expression. The opposite effects of this mutation on Ty and adjacent gene expression were probably caused by promoter competition.
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