ArticleEvoDevo2017
Developing an ancient epithelial appendage: FGF signalling regulates early tail denticle formation in sharks.
Article in EvoDevo, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Chemical and mechanical patterning of tortoise skin scales occur in different regions of the head.iScience · 2025Article
- Exacerbated sonic hedgehog signalling promotes a transition from chemical pre-patterning of chicken reticulate scales to mechanical skin folding.Open biology · 2025Article
- In vivo sonic hedgehog pathway antagonism temporarily results in ancestral proto-feather-like structures in the chicken.PLoS biology · 2025Article
- The emergence ofFrontiers in cell and developmental biology · 2025Article
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- The subfunctionalization ofFrontiers in cell and developmental biology · 2025Article
- Fgf signalling is required for gill slit formation in the skate, Leucoraja erinacea.Developmental biology · 2024Article
- Evo Devo of the Vertebrates Integument.Journal of developmental biology · 2023Review
- Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo.Science advances · 2023Article
- A shark-inspired general model of tooth morphogenesis unveils developmental asymmetries in phenotype transitions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Leafy and weedy seadragon genomes connect genic and repetitive DNA features to the extravagant biology of syngnathid fishes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates.eLife · 2022Article
- Redeployment of odontode gene regulatory network underlies dermal denticle formation and evolution in suckermouth armored catfish.Scientific reports · 2022Article
- Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution.Nature communications · 2021Article
- Growth trajectories of prenatal embryos of the deep-sea shark Chlamydoselachus anguineus (Chondrichthyes).Journal of fish biology · 2020Article
- Article
- Conserved gene signalling and a derived patterning mechanism underlie the development of avian footpad scales.EvoDevo · 2019Article
- An ancient Turing-like patterning mechanism regulates skin denticle development in sharks.Science advances · 2018Article
- An intronic enhancer of Bmp6 underlies evolved tooth gain in sticklebacks.PLoS genetics · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVertebrate epithelial appendages constitute a diverse group of organs that includes integumentary structures such as reptilian scales, avian feathers and mammalian hair. Recent studies have provided new evidence for the homology of integumentary organ development throughout amniotes, despite their disparate final morphologies. These structures develop from conserved molecular signalling centres, known as epithelial placodes. It is not yet certain whether this homology extends beyond the integumentary organs of amniotes, as there is a lack of knowledge regarding their development in basal vertebrates. As the ancient sister lineage of bony vertebrates, extant chondrichthyans are well suited to testing the phylogenetic depth of this homology. Elasmobranchs (sharks, skates and rays) possess hard, mineralised epithelial appendages called odontodes, which include teeth and dermal denticles (placoid scales). Odontodes constitute some of the oldest known vertebrate integumentary appendages, predating the origin of gnathostomes. Here, we used an emerging model shark (
resultsWe show that during early caudal denticle morphogenesis, the shark expresses homologues of conserved developmental gene families, known to comprise a core GRN for early placode morphogenesis in amniotes. This includes conserved expression of FGFs, sonic hedgehog (
conclusionOverall, these findings suggest the core GRN for building vertebrate integumentary epithelial appendages has been highly conserved over 450 million years. This provides evidence for the continuous, historical homology of epithelial appendage placodes throughout jawed vertebrates, from sharks to mammals. Epithelial placodes constitute the shared foundation upon which diverse vertebrate integumentary organs have evolved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.