ArticleJournal of human kinetics2017
IL-6, Antioxidant Capacity and Muscle Damage Markers Following High-Intensity Interval Training Protocols.
Article in Journal of human kinetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06043492 (Recovery Following Different Endurance Training Protocols in Middle- and Long-Distance Runners), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recovery Following Different Endurance Training Protocols in Middle- and Long-Distance Runners
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Effects of antioxidant supplementation on oxidative stress balance in young footballers- a randomized double-blind trial.Journal of the International Society of Sports Nutrition · 2021Trial
- Physiological Response Differences between Run and Cycle High Intensity Interval Training Program in Recreational Middle Age Female Runners.Journal of sports science & medicine · 2020Trial
- Salivary and Plasmatic Antioxidant Profile following Continuous, Resistance, and High-Intensity Interval Exercise: Preliminary Study.Oxidative medicine and cellular longevity · 2019Trial
- The Effect of a Single Bout of Exercise to Volitional Exhaustion Under Moderate Normobaric Hypoxia on the Kinetics of Cardiac Biomarkers in Trained and Untrained Men.International journal of molecular sciences · 2026Article
- The Dual Role of Interleukin-6 in the Pathophysiology of Skeletal Muscle: Mechanisms, Challenges, and Therapeutic Prospects.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Hematological and Biochemical Outcomes of Leishmania Infantum Infection in the South American Coati (Nasua nasua) in an Endemic Area of Visceral Leishmaniasis in Central Western Brazil.Acta parasitologica · 2026Article
- Exercise-modulated IL-6 in cancer cachexia: molecular mechanisms and therapeutic potential.Journal of translational medicine · 2026Review
- Inflammatory biomarkers in axial spondyloarthritis and the effect of moderate and high-intensity interval training - a narrative review.Molecular biology reports · 2025Review
- Comparison of Hormonal, Inflammatory, Muscle Damage and Oxidative Stress Biomarkers Changes in Response to High-Intensity Interval, Circuit and Concurrent Exercise Bouts.Sports (Basel, Switzerland) · 2025Article
- High-intensity interval training attenuates renal injury induced by myocardial ischemia-reperfusion in rats.Journal of the Chinese Medical Association : JCMA · 2025Article
- Mechanisms of the biological response cascade to exercise-induced stress: a comprehensive review.Frontiers in sports and active living · 2025Review
- Research Progress on the Effects of Different Exercise Modes on the Secretion of Exerkines After Spinal Cord Injury.Cellular and molecular neurobiology · 2024Review
- A Comparative Analysis of Acute Physiological and Perceptual Responses in Whole-Body and Ergometer-Based High-Intensity Interval Training Protocols.Sports (Basel, Switzerland) · 2024Article
- The Impact of Normobaric Hypoxia and Intermittent Hypoxic Training on Cardiac Biomarkers in Endurance Athletes: A Pilot Study.International journal of molecular sciences · 2024Article
- Effects of High-Intensity Interval Training on Melatonin Function and Cellular Lymphocyte Apoptosis in Sedentary Middle-Aged Men.Medicina (Kaunas, Lithuania) · 2023Article
- Bout duration in high-intensity interval exercise modifies hematologic, metabolic and antioxidant responses.Journal of exercise science and fitness · 2022Article
- Effects of High Intensity Exercise on Oxidative Stress and Antioxidant Status in Untrained Humans: A Systematic Review.Biology · 2021Review
- Sled dogs as a model for PM2.5 exposure from wildfires in Alaska.Environment international · 2021Article
- Changes in Anthropometric and Performance Parameters in High-Level Endurance Athletes during a Sports Season.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate changes of interleukin-6 (IL-6), total antioxidant capacity (TAC) and muscle damage markers (creatine kinase (CK), myoglobin and lactate dehydrogenase (LDH)) in response to three different high-intensity interval training (HIIT) protocols of identical external work. Twelve moderately-trained males participated in the three HIIT trials which consisted of a warm-up, followed by 12 min of 15 s, 30 s or 60 s HIIT sequences with the work/rest ratio 1. The biochemical markers of inflammation, oxidative stress and muscle damage were analysed POST, 3 h and 24 h after the exercise. All HIIT protocols caused an immediate increase in IL-6, TAC, CK, myoglobin and LDH. The most pronounced between-trials differences were found for the POST-exercise changes in IL-6 (Effect size ± 90% confidence interval: 1.51 ± 0.63, 0.84 ± 0.34 and 1.80 ± 0.60 for the 15s/15s, 30s/30s and 60s/60s protocol, respectively) and myoglobin (1.11 ± 0.29, 0.45 ± 0.48 and 1.09 ± 0.22 for the 15s/15s, 30s/30s and 60s/60s protocol, respectively). There were no substantial between-trial differences in other biochemical variables. In conclusion, the 15s/15s and 60s/60s protocols might be preferred to the 30s/30s protocols in order to maximize the training stimulus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.