Evidence map›Paper›PMID 28469697›Full record

ArticleInternational breastfeeding journal2016

Breastfeeding patterns and its determinants among mothers living with Human Immuno-deficiency Virus -1 in four African countries participating in the ANRS 12174 trial.

Eric N Somé, Ingunn M S Engebretsen, Nicolas Nagot, Nicolas Meda, Carl Lombard, Roselyne Vallo, Marianne Peries, Chipepo Kankasa, James K Tumwine, G Justus Hofmeyr and 5 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International breastfeeding journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00640263 (A Randomised Controlled Trial Comparing the Efficacy of Infant Peri-exposure Prophylaxis With Lopinavir/Ritonavir), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00640263 phase3completednot on this map

A Randomised Controlled Trial Comparing the Efficacy of Infant Peri-exposure Prophylaxis With Lopinavir/Ritonavir (LPV/r) Versus Lamivudine to Prevent HIV-1 Transmission by Breastfeeding

TypeinterventionalSponsorFrench National Agency for Research on AIDS and Viral HepatitisRan2009 to 2014Enrolled1,500ConditionsHIV InfectionsArmslopinavir/ritonavir (LPV/r), Lamivudine (3TC)
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 6 countries.

Eric N SoméCentre for International Health, University of Bergen, Bergen, Norway.
Ingunn M S EngebretsenCentre for International Health, University of Bergen, Bergen, Norway.
Nicolas NagotINSERM UMR 1058, Pathogenesis and control of chronic infections, Montpellier, France.
Nicolas MedaFaculty of Health Sciences, Centre de Recherche International en Santé (CRIS), University of Ouagadougou, Ouagadougou, Burkina Faso.
Carl LombardSouth African Medical Research Council, Biostatistics Unit, Cape Town, South Africa.
Roselyne ValloINSERM UMR 1058, Pathogenesis and control of chronic infections, Montpellier, France.
Marianne PeriesINSERM UMR 1058, Pathogenesis and control of chronic infections, Montpellier, France.
Chipepo KankasaDepartment of Paediatrics and Child Health, University of Zambia, School of Medicine, University Teaching Hospital, Lusaka, Zambia.
James K TumwineDepartment of Paediatrics and Child Health, College of Health Sciences, Makerere University, School of Medicine, Kampala, Uganda.
G Justus HofmeyrEffective Care Research Unit, University of Fort Hare, Eastern Cape, South Africa.
Mandisa SingataEffective Care Research Unit, University of Fort Hare, Eastern Cape, South Africa.
Kim HarperEffective Care Research Unit, University of Fort Hare, Eastern Cape, South Africa.
Philippe Van De PerreINSERM UMR 1058, Pathogenesis and control of chronic infections, Montpellier, France.
Thorkild TylleskarCentre for International Health, University of Bergen, Bergen, Norway.
ANRS 12174 Trial Group
Inserm · FRUniversity of Fort Hare · ZASouth African Medical Research Council · ZAUniversity of Bergen · NOCentre National de la Recherche Scientifique et Technologique · BFUniversité Joseph Ki-Zerbo · BFUniversity Teaching Hospital · ZM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHIV-1 transmission rates have been reduced over the last decade, an estimated 2 million new infections per year arise, including 220,000 paediatric cases. The main post-natal HIV exposure is through breastfeeding, where both its duration and modality (exclusive or not) are associated with postnatal transmission. The ANRS 12174 trial compared HIV-1 postnatal transmission of 2 prophylaxis drugs for infants during lactation (lamivudine and lopinavir-ritonavir). Our objective has been to examine the feeding practices and the determinants of exclusive/ predominant (EPBF) or any breastfeeding among the participants of this trial in Burkina Faso, South Africa, Uganda and Zambia.

methodsMothers infected with HIV-1 and their uninfected offspring were followed from day 7 after birth for 50 weeks, keeping monthly records of their feeding patterns. Feeding was classified into 3 categories: 1) exclusive breastfeeding during the first six months, only breast-milk being given to infant for 6 months, 2) predominant breastfeeding, breast-milk with liquid-based items being given, and 3) mixed feeding, other non-breast milk or solid food being given in addition to breast milk with or without liquid-based items. The categories were merged into 2 groups: EPBF applying to infants aged <6 months and mixed feeding applying to infants of any age. The feeding patterns have been given as Kaplan-Meier curves. A flexible parametric multiple regression model was used to identify the determinants of the mothers' feeding behaviour.

resultsA total of 1,225 mother-infant pairs provided feeding data from Burkina Faso (

conclusionsThere is a need to improve breastfeeding and complementary feeding practices of children, particularly those exposed to HIV and anti-retrovirals, taking into account context and socio-demographic factors.

trial registrationClinical trial registration: NCT00640263.

Indexed as

Cohort studyExclusive breastfeedingHIV infectionPreventionRisk factorsSub Saharan AfricaVertical transmission

Identifiers

PMID28469697
PMCPMC5414228
OpenAlexW2610611332

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.