Evidence map›Paper›PMID 28469667›Full record

ArticleNeural regeneration research2017

Transplantation of autologous peripheral blood mononuclear cells in the subarachnoid space for amyotrophic lateral sclerosis: a safety analysis of 14 patients.

Xiao-Yan Li, Zhan-Hua Liang, Chao Han, Wen-Juan Wei, Chun-Li Song, Li-Na Zhou, Yang Liu, Ying Li, Xiao-Fei Ji, Jing Liu

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. The landscape of neurophysiological outcome measures in ALS interventional trials: A systematic review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiao-Yan LiRegenerative Medicine Center, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.ORCID 0000-0001-5687-4004
Zhan-Hua LiangNeurological Department, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Chao HanRegenerative Medicine Center, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Wen-Juan WeiRegenerative Medicine Center, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Chun-Li SongElectromyography Department, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Li-Na ZhouElectromyography Department, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Yang LiuRegenerative Medicine Center, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Ying LiRegenerative Medicine Center, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Xiao-Fei JiNeurological Department, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Jing LiuRegenerative Medicine Center, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
First Affiliated Hospital of Dalian Medical University · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a small amount of clinical data regarding the safety and feasibility of autologous peripheral blood mononuclear cell transplantation into the subarachnoid space for the treatment of amyotrophic lateral sclerosis. The objectives of this retrospective study were to assess the safety and efficacy of peripheral blood mononuclear cell transplantation in 14 amyotrophic lateral sclerosis patients to provide more objective data for future clinical trials. After stem cell mobilization and collection, autologous peripheral blood mononuclear cells (1 × 10

Indexed as

adverse eventsamyotrophic lateral sclerosisautologousclinical researchnerve regenerationneural regenerationperipheral blood mononuclear cellssafetysubarachnoid space transplantation

Identifiers

PMID28469667
PMCPMC5399730
OpenAlexW2602440379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.