Evidence map›Paper›PMID 28469630›Full record

ReviewFrontiers in plant science2017

Abscisic Acid as Pathogen Effector and Immune Regulator.

Laurens Lievens, Jacob Pollier, Alain Goossens, Rudi Beyaert, Jens Staal

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in plant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 213 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Abscisic Acid MetabolizingPlants (Basel, Switzerland) · 2025
    Article
  9. In Silico Identification of Pathogenicity Effectors onBiotech (Basel (Switzerland)) · 2025
    Article
  10. Multi-step pathway engineering in probioticMetabolic engineering communications · 2025
    Article
  11. Article
  12. Comparative metagenomics of wild and cultivatedCurrent research in microbial sciences · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. An3 Biotech · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Gene and Its Promoter Cloning, and Functional Validation ofInternational journal of molecular sciences · 2024
    Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laurens LievensUnit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, VIBGhent, Belgium.
Jacob PollierVIB-UGent Center for Plant Systems Biology, VIBGhent, Belgium.
Alain GoossensVIB-UGent Center for Plant Systems Biology, VIBGhent, Belgium.
Rudi BeyaertUnit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, VIBGhent, Belgium.
Jens StaalUnit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, VIBGhent, Belgium.
Ghent University · BEVIB-UGent Center for Plant Systems Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abscisic acid (ABA) is a sesquiterpene signaling molecule produced in all kingdoms of life. To date, the best known functions of ABA are derived from its role as a major phytohormone in plant abiotic stress resistance. Different organisms have developed different biosynthesis and signal transduction pathways related to ABA. Despite this, there are also intriguing common themes where ABA often suppresses host immune responses and is utilized by pathogens as an effector molecule. ABA also seems to play an important role in compatible mutualistic interactions such as mycorrhiza and rhizosphere bacteria with plants, and possibly also the animal gut microbiome. The frequent use of ABA in inter-species communication could be a possible reason for the wide distribution and re-invention of ABA as a signaling molecule in different organisms. In humans and animal models, it has been shown that ABA treatment or nutrient-derived ABA is beneficial in inflammatory diseases like colitis and type 2 diabetes, which confer potential to ABA as an interesting nutraceutical or pharmacognostic drug. The anti-inflammatory activity, cellular metabolic reprogramming, and other beneficial physiological and psychological effects of ABA treatment in humans and animal models has sparked an interest in this molecule and its signaling pathway as a novel pharmacological target. In contrast to plants, however, very little is known about the ABA biosynthesis and signaling in other organisms. Genes, tools and knowledge about ABA from plant sciences and studies of phytopathogenic fungi might benefit biomedical studies on the physiological role of endogenously generated ABA in humans.

Indexed as

comparative biologyhost-microbe interactionsimmunityinflammationmetabolic engineeringnatural product chemistrysignal transductionsystems biology

Identifiers

PMID28469630
PMCPMC5395610
OpenAlexW2606991946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.