Evidence map›Paper›PMID 28469619›Full record

ArticleFrontiers in immunology2017

Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice.

Ira Ekmekciu, Eliane von Klitzing, Ulrike Fiebiger, Ulrike Escher, Christian Neumann, Petra Bacher, Alexander Scheffold, Anja A Kühl, Stefan Bereswill, Markus M Heimesaat

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 130 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ira EkmekciuDepartment of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.
Eliane von KlitzingDepartment of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.
Ulrike FiebigerDepartment of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.
Ulrike EscherDepartment of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.
Christian NeumannDepartment of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany.
Petra BacherDepartment of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany.
Alexander ScheffoldDepartment of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany.
Anja A KühlDepartment of Medicine I for Gastroenterology, Infectious Diseases and Rheumatology, Research Center ImmunoSciences (RCIS), Charité - University Medicine Berlin, Berlin, Germany.
Stefan BereswillDepartment of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.
Markus M HeimesaatDepartment of Microbiology and Hygiene, Charité - University Medicine Berlin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DELeibniz Association · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compelling evidence demonstrates the pivotal role of the commensal intestinal microbiota in host physiology and the detrimental effects of its perturbations following antibiotic treatment. Aim of this study was to investigate the impact of antibiotics induced depletion and subsequent restoration of the intestinal microbiota composition on the murine mucosal and systemic immunity. To address this, conventional C57BL/6j mice were subjected to broad-spectrum antibiotic treatment for 8 weeks. Restoration of the intestinal microbiota by peroral fecal microbiota transplantation (FMT) led to reestablishment of small intestinal CD4

Indexed as

antibioticsbacterial recolonizationfecal microbiota transplantationinnate and adaptive immunitymicrobiotamucosal and systemic immune responsessecondary abiotic (gnotobiotic) mice

Identifiers

PMID28469619
PMCPMC5395657
OpenAlexW2606652156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.