Evidence map›Paper›PMID 28469603›Full record

ArticleFrontiers in microbiology2017

Targeted Modification of a Novel Amphibian Antimicrobial Peptide from

Yitian Gao, Di Wu, Lei Wang, Chen Lin, Chengbang Ma, Xinping Xi, Mei Zhou, Jinao Duan, Olaf R P Bininda-Emonds, Tianbao Chen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Molecules (Basel, Switzerland) · 2023
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  11. Brevinin-2GHk fromAntibiotics (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Yitian GaoNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Di WuNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Lei WangNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Chen LinNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Chengbang MaNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Xinping XiNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Mei ZhouNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Jinao DuanJiangsu Key Laboratory for Traditional Chinese Medicine Formulae Research, Nanjing University of Chinese MedicineNanjing, China.
Olaf R P Bininda-EmondsAG Systematik und Evolutionsbiologie, IBU-Faculty V, Carl von Ossietzky University OldenburgOldenburg, Germany.
Tianbao ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Chris ShawNatural Drug Discovery Group, School of Pharmacy, Queen's University BelfastBelfast, UK.
Queen's University Belfast · GBCarl von Ossietzky Universität Oldenburg · DENanjing University of Chinese Medicine · CNZhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) in the skin secretions of amphibians are fundamental components of a unique defense system that has evolved to protect these hosts from microbial invasion. Medusins constitute a recently-discovered AMP family from phyllomedusine leaf frog skin and exhibit highly-conserved structural characteristics. Here, we report a novel medusin, medusin-PT, from the skin secretion of the Tarsier Leaf Frog,

Indexed as

amphibian skin secretionanalog designantibiofilmmedusinmolecular cloningMRSA

Identifiers

PMID28469603
PMCPMC5395648
OpenAlexW2607128509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.