ArticleFrontiers in behavioral neuroscience2017
In Search for Boundary Conditions of Reconsolidation: A Failure of Fear Memory Interference.
Article in Frontiers in behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: a systematic review and meta-analysis of clinical and 'sub-clinical' studies.Psychopharmacology · 2018Pooled it
- Pooled it
- Re-encountering the phobic cue within days after a reconsolidation intervention is crucial to observe a lasting fear reduction in spider phobia.Molecular psychiatry · 2025Trial
- Trial
- Neural substrates of propranolol-induced impairments in the reconsolidation of nicotine-associated memories in smokers.Translational psychiatry · 2021Trial
- Neurotransmitters in memory destabilization: An integrative perspective framed by prediction error and novelty.Cognitive, affective & behavioral neuroscience · 2026Review
- The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models.Translational psychiatry · 2024Article
- Fear attenuation collaborations to optimize translation.Behavioral neuroscience · 2024Article
- Appraising reconsolidation theory and its empirical validation.Psychonomic bulletin & review · 2023Review
- Modulation of methamphetamine memory reconsolidation by neural projection from basolateral amygdala to nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The elegant complexity of fear in non-human animals.Emerging topics in life sciences · 2022Article
- Behavioural reconsolidation interference not observed in a within-subjects design.NPJ science of learning · 2022Article
- Over the Edge: Extending the duration of a reconsolidation intervention for spider fear.Translational psychiatry · 2022Article
- Demarcating the boundary conditions of memory reconsolidation: An unsuccessful replication.Scientific reports · 2022Article
- Interfering With Contextual Fear Memories by Post-reactivation Administration of Propranolol in Mice: A Series of Null Findings.Frontiers in behavioral neuroscience · 2022Article
- Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval.Frontiers in behavioral neuroscience · 2022Article
- Propranolol Decreases Fear Expression by Modulating Fear Memory Traces.Biological psychiatry · 2021Article
- Evaluation of an angiotensin Type 1 receptor blocker on the reconsolidation of fear memory.Translational psychiatry · 2020Article
- Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.Scientific reports · 2020Article
- Editorial: Overcome Fear and Addiction by Manipulating Reconsolidation and Extinction of Emotional Memories.Frontiers in behavioral neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The presentation of a fear memory cue can result in mere memory retrieval, destabilization of the reactivated memory trace, or the formation of an extinction memory. The interaction between the degree of novelty during reactivation and previous learning conditions is thought to determine the outcome of a reactivation session. This study aimed to evaluate whether contextual novelty can prevent cue-induced destabilization and disruption of a fear memory acquired by non-asymptotic learning. To this end, fear memory was reactivated in a novel context or in the original context of learning, and fear memory reactivation was followed by the administration of propranolol, an amnestic drug. Remarkably, fear memory was not impaired by post-reactivation propranolol administration or extinction training under the usual conditions used in our lab, irrespective of the reactivation context. These unexpected findings are discussed in the light of our current experimental parameters and alleged boundary conditions on memory destabilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.