Evidence map›Paper›PMID 28469396›Full record

ArticleBiomarker insights2017

Expression of Reactive Oxygen Species-Related Transcripts in Egyptian Children With Autism.

Nagwa A Meguid, Said A S Ghozlan, Magda F Mohamed, Marwa K Ibrahim, Reham M Dawood, Noha G Bader El Din, Tawfeek H Abdelhafez, Maha Hemimi, Mostafa K El Awady

Open access · goldAbstract read
In one paragraph

Article in Biomarker insights, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  8. Review
  9. Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nagwa A MeguidDepartment of Research on Children with Special Needs, Medical Research Division, National Research Centre, Giza, Egypt.
Said A S GhozlanDepartment of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
Magda F MohamedDepartment of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza, Egypt.
Marwa K IbrahimMicrobial Biotechnology Department, Genetic Engineering Division, National Research Centre, Giza, Egypt.
Reham M DawoodMicrobial Biotechnology Department, Genetic Engineering Division, National Research Centre, Giza, Egypt.
Noha G Bader El DinMicrobial Biotechnology Department, Genetic Engineering Division, National Research Centre, Giza, Egypt.
Tawfeek H AbdelhafezMicrobial Biotechnology Department, Genetic Engineering Division, National Research Centre, Giza, Egypt.
Maha HemimiDepartment of Research on Children with Special Needs, Medical Research Division, National Research Centre, Giza, Egypt.
Mostafa K El AwadyMicrobial Biotechnology Department, Genetic Engineering Division, National Research Centre, Giza, Egypt.
National Research Centre · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular basis of the pathophysiological role of oxidative stress in autism is understudied. Herein, we used polymerase chain reaction (PCR) array to analyze transcriptional pattern of 84 oxidative stress genes in peripheral blood mononuclear cell pools isolated from 32 autistic patients (16 mild/moderate and 16 severe) and 16 healthy subjects (each sample is a pool from 4 autistic patients or 4 controls). The PCR array data were further validated by quantitative real-time PCR in 80 autistic children (55 mild/moderate and 25 severe) and 60 healthy subjects. Our data revealed downregulation in

Indexed as

Autismgene expressionneurodevelopmental disordersoxidative stressPCR arrayROS

Identifiers

PMID28469396
PMCPMC5391985
OpenAlexW2591238185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.