A rare case of Crohn's ileitis in a patient with constitutional mismatch repair deficiency.

Pavlos Kaimakliotis, Francis Giardiello, Ogechukwu Eze, Brindusa Truta

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In one paragraph

Article in Annals of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 98% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Constitutional Mismatch Repair Deficiency: Scoping Review of a Cancer-Predisposition Syndrome With Distinctive Cutaneous Findings.Pediatric dermatology
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Pavlos KaimakliotisDepartment of Medicine (Pavlos Kaimakliotis, Francis Giardiello, Brindusa Truta).

Francis GiardielloDepartment of Medicine (Pavlos Kaimakliotis, Francis Giardiello, Brindusa Truta).

Ogechukwu EzePathology (Ogechukwu Eze), Johns Hopkins University, School of Medicine, USA.

Brindusa TrutaDepartment of Medicine (Pavlos Kaimakliotis, Francis Giardiello, Brindusa Truta).

Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Constitutional mismatch repair deficiency (CMMRD), a variant of Lynch syndrome, is a rare disease characterized by café-au-lait spots, oligopolyposis, glioblastoma and lymphoma. A 24-year-old male, under surveillance for CMMRD, developed Crohn's ileitis after total colectomy with end ileostomy for colorectal cancer and failed to respond to oral corticosteroids. The patient underwent induction and maintenance of remission with vedolizumab infusions. We report the first patient with CMMRD developing Crohn's disease. The choice of immunosuppressive therapy in these patients is challenging and needs to be made according to their risk for malignancy.

Indexed as

constitutional mismatch repair deficiencyCrohn’s diseasefamilial cancervedolizumab

Identifiers

PMID28469372

DOI10.20524/aog.2017.0129

PMCPMC5411392

OpenAlexW2588846452

What OpenQuestion holds

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LicenceCC BY-NC-SA

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.