ArticleScientific reports2017
Protective effect of antioxidants on the pre-maturation aging of mouse oocytes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Effect of Melatonin and Epigallocatechin-3-Gallate Combination on In Vitro Maturation of Mouse Oocytes.International journal of molecular sciences · 2026Article
- Molecular mechanisms underlying cyclophosphamide-induced ovarian injury and protective strategies.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- The effect of endometriosis on oocyte quality: mechanisms, diagnosis and treatment.Archives of gynecology and obstetrics · 2025Review
- Article
- Synergistic Effects of Capsaicin and Quercetin Improved Induced Premature Ovarian Failure in Rat.Cell journal · 2023Article
- Effect and mechanism of pearl on ovarian function of rats with premature ovarian failure induced by tripterygium glycosides.Journal of traditional and complementary medicine · 2023Article
- Nonerythroid hemoglobin promotes human cumulus cell viability and the developmental capacity of the human oocyte.F&S science · 2023Article
- Study on the Mechanism of Hydrolyzed Seawater Pearl Tablet in Treating Chronic Sleep Deprivation Mice Model.Endocrine, metabolic & immune disorders drug targets · 2023Article
- Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Role of N-acetylcysteine treatment in women with advanced age undergoing IVF/ICSI cycles: A prospective study.Frontiers in medicine · 2022Article
- N-acetyl-L-cysteine Improves the Developmental Competence of Bovine Oocytes and Embryos Cultured In Vitro by Attenuating Oxidative Damage and Apoptosis.Antioxidants (Basel, Switzerland) · 2021Article
- In Vitro Maturation of Fully Grown Mouse Antral Follicles in the Presence of 1 nM 2-Hydroxyestradiol Improves Oocytes' Developmental Competence.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Antimüllerian hormone and F2-isoprostanes in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.Fertility and sterility · 2020Article
- Beneficial Effects of Melatonin in the Ovarian Transport Medium on In Vitro Embryo Production of Iberian Red Deer (Animals : an open access journal from MDPI · 2020Article
- Maternal transmission of mitochondrial diseases.Genetics and molecular biology · 2020Article
- The effect of maternal high-fat/high-sugar diet on offspring oocytes and early embryo development.Molecular human reproduction · 2019Article
- Mitochondrial Dysfunction in Primary Ovarian Insufficiency.Endocrinology · 2019Review
- Influence of N-acetyl-L-cysteine against bisphenol a on the maturation of mouse oocytes and embryo development: in vitro study.BMC pharmacology & toxicology · 2019Article
- Endogenous and Exogenous Modulation of Nrf2 Mediated Oxidative Stress Response in Bovine Granulosa Cells: Potential Implication for Ovarian Function.International journal of molecular sciences · 2019Article
- Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model.Journal of ovarian research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte. Oxidative stress is one of the most detrimental factors affecting oocyte developmental competence and maturation during aging. In this study, experiments were designed to examine whether supplementation of antioxidants in a culture medium could protect immature mouse oocytes from damages caused by oxidative stress. Mouse oocytes at germinal vesicle stage were prevented from meiosis resumption and cultured in a medium with or without antioxidants for 12-36 h to allow oocytes to undergo aging. After aging, oocytes were cultured for maturation. Nuclear maturation, mitochondria activity, spindle morphology and DNA integrity were examined after maturation. It was found that antioxidants had protective effects on the oocytes in terms of nuclear maturation, functional mitochondria, spindle morphology and DNA integrity. As aging time was prolonged from 12 to 36 h, the protective effect of antioxidants became more obvious. However, as compared with oocytes without aging, it was found that aging significantly inhibited nuclear maturation, impaired mitochondria function, and damaged the spindle and DNA. These results indicate that pre-maturation aging is detrimental to oocytes' competence to undergo maturation and other cellular activities, and antioxidants can protect oocytes from damages caused by aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.