ReviewChinese medical journal2017
Vascular Calcification: Current Genetics Underlying This Complex Phenomenon.
Review in Chinese medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- The role of sortilin in cardiovascular calcification: mechanisms and therapeutic potential.Frontiers in cardiovascular medicine · 2026Review
- Construction and validation of a risk prediction model for extensive abdominal aortic calcification in hypertensive patients aged 40 and above: a cross-sectional study based on the 2013-2014 NHANES database.BMC cardiovascular disorders · 2025Article
- Composite dietary antioxidant index and abdominal aortic calcification: a national cross-sectional study.Nutrition journal · 2024Article
- Comparative analysis of calcified soft tissues revealed shared deregulated pathways.Frontiers in aging neuroscience · 2023Article
- Histopathological assessment of radial artery calcification in patients with end-stage kidney disease.Renal failure · 2021Article
- Histology and Immunohistochemistry of Radial Arteries Are Suggestive of an Interaction between Calcification and Early Atherosclerotic Lesions in Chronic Kidney Disease.Medicina (Kaunas, Lithuania) · 2021Article
- An update on vascular calcification and potential therapeutics.Molecular biology reports · 2021Review
- High dose haemodialysis and haemodiafiltration parameters and the relationship with advanced vascular calcification.BMC nephrology · 2020Observational
- Vascular calcification; Stony bridge between kidney and heart.Journal of cardiovascular and thoracic research · 2020Review
- Vascular Calcification: An Important Understanding in Nephrology.Vascular health and risk management · 2020Review
- High Mobility Group Box 1 Promotes Aortic Calcification in Chronic Kidney Disease via the Wnt/β-Catenin Pathway.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveVascular calcification is the consequence of the complex interaction between genetic, environmental, and vascular factors, which ultimately lead to the deposition of calcium in the tunica intima (atherosclerotic calcification) or tunica media (Mönckenberg's sclerosis). Vascular calcification is also closely related to other pathologies, such as diabetes mellitus, dyslipidemia, and chronic kidney disease. It has been concluded that the degree of vascular calcification may vary from person to person, even if the associated pathologies and environmental factors are the same. Therefore, this suggests an important genetic contribution to the development of vascular calcification. This review aimed to find the most recent evidence about vascular calcification pathophysiology regarding the genetic aspects and molecular pathways. DATA SOURCES: We conducted an exhaustive search in Scopus, EBSCO, and PubMed with the keywords "genetics and vascular calcification", "molecular pathways, genetic and vascular calcification" and included the main articles from January 1995 up to August 2016. We focused on the most recent evidence about vascular calcification pathophysiology regarding the genetic aspects and molecular pathways. STUDY SELECTION: The most valuable published original and review articles related to our objective were selected.
resultsVascular calcification is a multifactorial disease; thus, its pathophysiology cannot be explained by a single specific factor, rather than by the result of the association of several genetic variants, molecular pathway interactions, and environmental factors that promote its development.
conclusionAlthough several molecular aspects of this mechanism have been elucidated, there is still a need for a better understanding of the factors that predispose to this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.