ArticleJCI insight2017
Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.
Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Ferritin and transferrin predict common carotid intima-media thickness in females: a machine-learning informed individual participant data meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Acellular Hemoglobin Impairs Cardiomyocyte Excitation-Contraction Coupling.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Molecular Mechanisms of Transfusion-Associated Immunomodulation and Its Impact in the Critically Ill.International journal of molecular sciences · 2025Review
- Assessment of natural killer cell subpopulations in pediatric patients with transfusion-dependent β-thalassemia major.Clinical and experimental pediatrics · 2025Article
- Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice.Biotechnology and bioengineering · 2025Article
- Ultraviolet light and riboflavin accelerates red blood cell dysfunction in vitro and in a guinea pig transfusion model.Blood transfusion = Trasfusione del sangue · 2024Article
- Novel high molecular weight polymerized hemoglobin in a non-obese model of cardiovascular and metabolic dysfunction.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Article
- Article
- Hemoglobin Oxidation Reactions in Stored Blood.Antioxidants (Basel, Switzerland) · 2022Article
- Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes.The Journal of clinical investigation · 2020Article
- ZOOMICS: Comparative Metabolomics of Red Blood Cells From Old World Monkeys and Humans.Frontiers in physiology · 2020Article
- Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia.The Journal of clinical investigation · 2019Article
- Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.The Journal of clinical investigation · 2019Article
- Revisiting the putative role of heme as a trigger of inflammation.Pharmacology research & perspectives · 2018Article
- Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.BMC biotechnology · 2018Article
- Mechanisms of red blood cell transfusion-related immunomodulation.Transfusion · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions. This study investigated transfusion, vascular disease, and mortality in guinea pigs after stored RBC transfusion alone and following cotransfusion with apo-transferrin (apo-Tf) and haptoglobin (Hp). The effects of RBC exchange transfusion dose (1, 3, and 9 units), storage period (14 days), and mortality were evaluated in guinea pigs with a vascular disease phenotype. Seven-day mortality and the interaction between iron and Hb as cocontributors to adverse outcome were studied. Concentrations of iron and free Hb were greatest after transfusion with 9 units of stored RBCs compared with fresh RBCs or stored RBCs at 1- and 3-unit volumes. Nine units of stored RBCs led to mortality in vascular diseased animals, but not normal animals. One and 3 units of stored RBCs did not cause a mortality effect, suggesting the concomitant relevance of NTBI and Hb on outcome. Cotransfusion with apo-Tf or Hp restored survival to 100% following 9-unit RBC transfusions in vascular diseased animals. Our data suggest that increases in plasma NTBI and Hb contribute to vascular disease-associated mortality through iron-enhanced Hb oxidation and enhanced tissue injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.