ArticleScience translational medicine2017
Nociceptive brain activity as a measure of analgesic efficacy in infants.
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial intelligence in pediatric pain: a systematic review.BMC medical informatics and decision making · 2026Pooled it
- Impact of breast milk on cortical pain response in newborns during the heel prick procedure: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK.The Lancet. Child & adolescent health · 2024Trial
- Trial
- Breastmilk as a Multisensory Intervention for Relieving Pain during Newborn Screening Procedures: A Randomized Control Trial.International journal of environmental research and public health · 2021Trial
- Birth experience in newborn infants is associated with changes in nociceptive sensitivity.Scientific reports · 2019Trial
- Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial.Lancet (London, England) · 2018Trial
- Electroencephalography during acute painful procedures in neonates: a scoping review.Pain reports · 2026Review
- Machine learning classification of EEG responses to pain-related vs non-pain-related stimulus in preterm infants.Pain reports · 2025Article
- Article
- Prefrontal Cortical Near-Infrared Spectroscopy for Acute Pain Assessment in Infants: A Feasibility Study.Journal of clinical medicine · 2025Article
- Objective Detection of Newborn Infant Acute Procedural Pain Using EEG and Machine Learning Algorithms.Paediatric & neonatal pain · 2025Article
- Moments that matter: childhood pain treatment shapes pain for life-we can do better every time in every child.BMC medicine · 2025Article
- Establishing a standardised approach for the measurement of neonatal noxious-evoked brain activity in response to an acute somatic nociceptive heel lance stimulus.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Measuring Pain in Neonates and Young Infants.Indian journal of pediatrics · 2024Article
- A machine learning artefact detection method for single-channel infant event-related potential studies.Journal of neural engineering · 2024Article
- Multisensory stimuli and pain perception in the newborn.Pediatric research · 2024Article
- Sensory event-related potential morphology predicts age in premature infants.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- EEG-based sensory testing reveals altered nociceptive processing in elite endurance athletes.Experimental brain research · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pain in infants is undertreated and poorly understood, representing a major clinical problem. In part, this is due to our inability to objectively measure pain in nonverbal populations. We present and validate an electroencephalography-based measure of infant nociceptive brain activity that is evoked by acute noxious stimulation and is sensitive to analgesic modulation. This measure should be valuable both for mechanistic investigations and for testing analgesic efficacy in the infant population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.