ArticleProceedings. Biological sciences2017
The active force-length relationship is invisible during extensive eccentric contractions in skinned skeletal muscle fibres.
Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 49 citations in OpenAlex.
- Cross-bridge model for predicting muscle short-range stiffness during movement.PLoS computational biology · 2026Article
- Effects of chemical myosin II cross-bridge inhibitors on eccentric force production in skinned muscle fibres.Experimental physiology · 2026Article
- Starting length and temperature dependence of eccentric muscle force-velocity behaviour.The Journal of experimental biology · 2026Article
- How temperature tunes muscle mechanics during eccentric contractions.American journal of physiology. Cell physiology · 2026Article
- Consecutive SSCs increase the SSC effect in skinned rat muscle fibres.Pflugers Archiv : European journal of physiology · 2025Article
- Residual force enhancement is not altered while force depression is amplified at the cellular level in old age.The Journal of experimental biology · 2025Article
- Impact of lengthening velocity on the generation of eccentric force by slow-twitch muscle fibers in long stretches.Pflugers Archiv : European journal of physiology · 2024Article
- The impacts of muscle-specific force-velocity properties on predictions of mouse muscle function during locomotion.Frontiers in bioengineering and biotechnology · 2024Article
- Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics.Pflugers Archiv : European journal of physiology · 2023Review
- Role of Rotated Head Postures on Volunteer Kinematics and Muscle Activity in Braking Scenarios Performed on a Driving Simulator.Annals of biomedical engineering · 2023Article
- Muscle preflex response to perturbations in locomotion:Frontiers in bioengineering and biotechnology · 2023Article
- Ultrastructural and kinetic evidence support that thick filaments slide through the Z-disc.Journal of the Royal Society, Interface · 2022Article
- Hamstrings force-length relationships and their implications for angle-specific joint torques: a narrative review.BMC sports science, medicine & rehabilitation · 2022Review
- Fast stretching of skeletal muscle fibres abolishes residual force enhancement.The Journal of experimental biology · 2022Article
- Cross-bridge mechanics estimated from skeletal muscles' work-loop responses to impacts in legged locomotion.Scientific reports · 2021Article
- A mutation in desmin makes skeletal muscle less vulnerable to acute muscle damage after eccentric loading in rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- The effect of stretch-shortening magnitude and muscle-tendon unit length on performance enhancement in a stretch-shortening cycle.Scientific reports · 2021Article
- Titin N2A Domain and Its Interactions at the Sarcomere.International journal of molecular sciences · 2021Review
- Power Amplification Increases With Contraction Velocity During Stretch-Shortening Cycles of Skinned Muscle Fibers.Frontiers in physiology · 2021Article
- Biarticular muscles in light of template models, experiments and robotics: a review.Journal of the Royal Society, Interface · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to experimentally observed progressive forces in eccentric contractions, cross-bridge and sliding-filament theories of muscle contraction predict that varying myofilament overlap will lead to increases and decreases in active force during eccentric contractions. Non-cross-bridge contributions potentially explain the progressive total forces. However, it is not clear whether underlying abrupt changes in the slope of the nonlinear force-length relationship are visible in long isokinetic stretches, and in which proportion cross-bridges and non-cross-bridges contribute to muscle force. Here, we show that maximally activated single skinned rat muscle fibres behave (almost across the entire working range) like linear springs. The force slope is about three times the maximum isometric force per optimal length. Cross-bridge and non-cross-bridge contributions to the muscle force were investigated using an actomyosin inhibitor. The experiments revealed a nonlinear progressive contribution of non-cross-bridge forces and suggest a nonlinear cross-bridge contribution similar to the active force-length relationship (though with increased optimal length and maximum isometric force). The linear muscle behaviour might significantly reduce the control effort. Moreover, the observed slight increase in slope with initial length is in accordance with current models attributing the non-cross-bridge force to titin.
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