Evidence map›Paper›PMID 28469007›Full record

ReviewOpen biology2017

Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer.

Guia Carrara, Maddy Parsons, Nuno Saraiva, Geoffrey L Smith

Open access · goldAbstract readReview
In one paragraph

Review in Open biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Intracellular CaBiologia futura · 2025
    Review
  4. The Golgi CaBiophysics reports · 2024
    Article
  5. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Bcl-2-Protein Family as Modulators of IPCold Spring Harbor perspectives in biology · 2020
    Review
  16. Article
  17. Review
  18. Article
  19. Deciphering GRINA/Lifeguard1: Nuclear Location, CaInternational journal of molecular sciences · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Guia CarraraDepartment of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
Maddy ParsonsRandall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, UK.ORCID 0000-0002-2021-8379
Nuno SaraivaDepartment of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK nuno.saraiva@ulusofona.pt.ORCID 0000-0003-1333-9137
Geoffrey L SmithDepartment of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK gls37@cam.ac.uk.ORCID 0000-0002-3730-9955
University of Cambridge · GBKing's College London · GB

Funding

Medical Research Council G0900224Wellcome TrustWellcome Trust 085295
6 · The paper itself

Abstract

Golgi anti-apoptotic protein (GAAP), also known as transmembrane Bax inhibitor-1 motif-containing 4 (TMBIM4) or Lifeguard 4 (Lfg4), shares remarkable amino acid conservation with orthologues throughout eukaryotes, prokaryotes and some orthopoxviruses, suggesting a highly conserved function. GAAPs regulate Ca

Indexed as

AnimalsApoptosisCalciumCamelusEndoplasmic ReticulumGolgi ApparatusHumansIon ChannelsMembrane ProteinsNeoplasmsCalciumIon ChannelsMembrane ProteinsTMBIM4 protein, humanBax inhibitor-1, TMBIMcalcium fluxcell adhesion and migrationGolgi anti-apoptotic proteinion channel

Identifiers

PMID28469007
PMCPMC5451544
OpenAlexW2610693869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.