ArticleCirculation2017
Physiology of Angina and Its Alleviation With Nitroglycerin: Insights From Invasive Catheter Laboratory Measurements During Exercise.
Open access · goldAbstract read
In one paragraph
Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Perioperative diltiazem or nitroglycerin in on-pump coronary artery bypass: A systematic review and network meta-analysis.PloS one · 2018Pooled it
- Trial
- Seasonal patterns in diagnosis of coronary artery disease by CT-angiography-experience from a large real-world cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Cardiovascular endpoints in relation to the central arterial pressure-time indexes.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Comparison of Nitroglycerin-Induced Pressure Ratio Drop and Resting Full-Cycle Ratio in a Pressure Wire Study.Journal of clinical medicine · 2024Article
- Coumarin-Furoxan Hybrid Suppressed the Proliferation and Metastasis of Triple-Negative Breast Cancer by Activating Mitochondrial Stress and Cell Apoptosis.ACS pharmacology & translational science · 2024Article
- Therapeutic gas-releasing nanomedicines with controlled release: Advances and perspectives.Exploration (Beijing, China) · 2022Review
- Physiological Impact of Afterload Reduction on Cardiac Mechanics and Coronary Hemodynamics Following Isosorbide Dinitrate Administration in Ischemic Heart Disease.Journal of cardiovascular translational research · 2021Article
- Impact of coronary artery disease on contractile function and ventricular-arterial coupling during exercise: Simultaneous assessment of left-ventricular pressure-volume and coronary pressure and flow during cardiac catheterization.Physiological reports · 2021Observational
- Angina: contemporary diagnosis and management.Heart (British Cardiac Society) · 2020Review
- Coronary Microcirculation in Aortic Stenosis.Circulation. Cardiovascular interventions · 2019Review
- Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease.Journal of the American College of Cardiology · 2018Article
- Deleterious Effects of Cold Air Inhalation on Coronary Physiological Indices in Patients With Obstructive Coronary Artery Disease.Journal of the American Heart Association · 2018Article
- Systemic glyceryl trinitrate reduces anal sphincter tone: is there a therapeutic indication?Irish journal of medical science · 2018Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 2 countries.
Kaleab N AsrressFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.). kaleab.asrress@sydney.edu.au.
Rupert WilliamsFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Timothy LockieFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Muhammed Z KhawajaFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Kalpa De SilvaFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Matthew LumleyFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Tiffany PattersonFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Satpal ArriFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Sana IhsanFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Howard EllisFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Antoine GuilcherFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Brian ClappFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Philip J ChowienczykFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Sven PleinFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Divaka PereraFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Michael S MarberFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
Simon R RedwoodFrom King's College London British Heart Foundation Centre of Excellence, Rayne Institute, St. Thomas' Hospital, London, United Kingdom (K.N.A., R.W., T.L., M.Z.K., K.D.S., M.L., T.P., S.A., H.E., D.P., M.S.M., S.R.R.); National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom (K.N.A., M.S.M., S.R.R.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (K.N.A., K.D.S.); Kolling Institute, Northern Clinical School, University of Sydney, Australia (K.N.A.); Department of Clinical Pharmacology (A.G., P.J.C.) and Division of Imaging Sciences and Biomedical Engineering, Rayne Institute (S.I., S.P.), St Thomas' Hospital, King's College London, London, United Kingdom; Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom (B.C.); and Division of Cardiovascular and Neuronal Remodelling, University of Leeds, United Kingdom (S.P.).
King's College London · GBSt Thomas' Hospital · GBUniversity of Sydney · AUGuy's and St Thomas' NHS Foundation Trust · GBNational Institute for Health Research · GBNIHR Biomedical Research Centre at The Royal Marsden and the ICRNorthern Sydney Local Health District · AURoyal North Shore Hospital · AU
Funding
British Heart Foundation CS/16/3/32615British Heart Foundation FS/10/62/28409British Heart Foundation FS/11/43/28760British Heart Foundation FS/11/90/29087British Heart Foundation FS/12/15/29380British Heart Foundation FS/13/15/30026British Heart Foundation FS/14/11/30526
Abstract
backgroundThe mechanisms governing exercise-induced angina and its alleviation by the most commonly used antianginal drug, nitroglycerin, are incompletely understood. The purpose of this study was to develop a method by which the effects of antianginal drugs could be evaluated invasively during physiological exercise to gain further understanding of the clinical impact of angina and nitroglycerin.
methodsForty patients (mean age, 65.2±7.6 years) with exertional angina and coronary artery disease underwent cardiac catheterization via radial access and performed incremental exercise using a supine cycle ergometer. As they developed limiting angina, sublingual nitroglycerin was administered to half the patients, and all patients continued to exercise for 2 minutes at the same workload. Throughout exercise, distal coronary pressure and flow velocity and central aortic pressure were recorded with sensor wires.
resultsPatients continued to exercise after nitroglycerin administration with less ST-segment depression (
conclusionsThe catheterization laboratory protocol provides a model to study myocardial ischemia and the actions of novel and established antianginal drugs. Administration of nitroglycerin causes changes in the systemic and coronary circulation that combine to reduce myocardial oxygen demand and to increase supply, thereby attenuating exercise-induced ischemia. Designing antianginal therapies that exploit these mechanisms may provide new therapeutic strategies.
Indexed as
AgedAngina PectorisCardiac CatheterizationEchocardiography, DopplerExercise TestFemaleHumansMaleMiddle AgedNitroglycerinPulse Wave AnalysisSingle-Blind MethodVasodilator AgentsNitroglycerinVasodilator Agentsangina pectoriscoronary circulationexercisemyocardial ischemianitroglycerinphysiology
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