Evidence map›Paper›PMID 28468973›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

IL-1R Type 1-Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection.

Tian Tian, Michelle Qiushuang Jin, Krista Dubin, Sandra L King, Wolfram Hoetzenecker, George F Murphy, Chen Amy Chen, Thomas S Kupper, Robert C Fuhlbrigge

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Role of lamin A/C on dendritic cell function in antiviral immunity.Cellular and molecular life sciences : CMLS · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Tian TianDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; ttian@partners.org Robert.Fuhlbrigge@childrenscolorado.org.
Michelle Qiushuang JinStanford University, Stanford, CA 94305.
Krista DubinWeill Cornell Medical College, New York, NY 10065.ORCID 0000-0002-1915-3723
Sandra L KingDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Wolfram HoetzeneckerDepartment of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland.
George F MurphyDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Chen Amy ChenHarvard Medical School, Boston, MA 02115; and.
Thomas S KupperDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Robert C FuhlbriggePediatric Rheumatology, University of Colorado-Denver, Aurora, CO 80045 ttian@partners.org Robert.Fuhlbrigge@childrenscolorado.org.
Brigham and Women's Hospital · USCornell University · USHarvard University · USStanford University · USUniversity Hospital of Zurich · CHUniversity of Colorado Denver · US

Funding

Virus discovery in cutaneous T cell lymphomaP30AR042689 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUPPER, THOMAS S. · 1994 to 2010
$6.8M
Skin Homing T CellsR01AR065807 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUPPER, THOMAS S. · 2013 to 2022
$6.3M
Vaccination to generate protective tissue resident T cellsR01AI097128 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN, KUPPER, THOMAS S. · 2011 to 2015
$6.1M
NIAID NIH HHS HHSN266200400030CNIAID NIH HHS R01 AI097128NIAMS NIH HHS P30 AR042689NIAMS NIH HHS R01 AR065807
6 · The paper itself

Abstract

The IL-1 superfamily of cytokines and receptors has been studied extensively. However, the specific roles of IL-1 elements in host immunity to cutaneous viral infection remain elusive. In this study, we applied vaccinia virus (VACV) by scarification to IL-1R1 knockout mice (IL-1R1

Indexed as

Administration, CutaneousAnimalsCD8-Positive T-LymphocytesInterleukin 1 Receptor Antagonist ProteinKaposi Varicelliform EruptionMiceMice, Inbred C57BLMice, KnockoutSkinSkin Diseases, InfectiousVaccinationVacciniaVaccinia virusVirus ReplicationInterleukin 1 Receptor Antagonist Protein

Identifiers

PMID28468973
PMCPMC5506850
OpenAlexW2611204180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.