Evidence map›Paper›PMID 28468964›Full record

ArticleAmerican journal of physiology. Renal physiology2017

Luminal ANG II is internalized as a complex with AT

Fernanda M Ferrão, Luiza H D Cardoso, Heather A Drummond, Xiao C Li, Jia L Zhuo, Dayene S Gomes, Lucienne S Lara, Adalberto Vieyra, Jennifer Lowe

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Plants (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Review
  4. The Angiotensin ATPharmacological reviews · 2022
    Review
  5. Review
  6. Review
  7. Investigation of Receptor Heteromers Using NanoBRET Ligand Binding.International journal of molecular sciences · 2021
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Mitochondrial angiotensin receptors and cardioprotective pathways.American journal of physiology. Heart and circulatory physiology · 2019
    Review
  13. Article
  14. Article
  15. Review
  16. Dimerization of ATCurrent hypertension reports · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Fernanda M FerrãoLaboratório de Físico-Química Biológica Aída Hassón-Voloch, Instituto de Biofísica Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Luiza H D CardosoLaboratório de Físico-Química Biológica Aída Hassón-Voloch, Instituto de Biofísica Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Heather A DrummondDepartment of Physiology and Biophysics and the Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi.
Xiao C LiDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Jia L ZhuoDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Dayene S GomesInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Lucienne S LaraInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Adalberto VieyraLaboratório de Físico-Química Biológica Aída Hassón-Voloch, Instituto de Biofísica Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Jennifer LoweLaboratório de Físico-Química Biológica Aída Hassón-Voloch, Instituto de Biofísica Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; lowe@biof.ufrj.br.ORCID http://orcid.org/0000-0001-7378-4561
Universidade Federal do Rio de Janeiro · BRUniversity of Mississippi Medical Center · US

Funding

Role of Intracrine Angiotensin II in Kidney CellsR01DK067299 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jia Long Zhuo · 2004 to 2026
$6.5M
Role of Proximal Tubule NHE3 in Angiotensin II-induced HypertensionR01DK102429 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2014 to 2021
$2.5M
The Na+/H+ Exchanger 3, Pressure Natriuresis, and HypertensionR56HL130988 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2016 to 2016
$381k
Novel Roles of Intracrine Angiotensin II in Proximal Tubule CellsR56DK067299 · NIDDK · HENRY FORD HEALTH SYSTEM · PI ZHUO, JIA LONG · 2009 to 2009
$352k
NHLBI NIH HHS R56 HL130988NIDDK NIH HHS R01 DK067299NIDDK NIH HHS R01 DK102429NIDDK NIH HHS R56 DK067299
6 · The paper itself

Abstract

ANG II has many biological effects in renal physiology, particularly in Ca

Indexed as

EndocytosisAngiotensin IIAngiotensin II Type 1 Receptor BlockersAngiotensin II Type 2 Receptor BlockersAnimalsbeta-ArrestinsCalciumCell MembraneEndoplasmic ReticulumKidneyLLC-PK1 CellsMicrotubulesMultiprotein ComplexesPhosphorylationProtein Kinase C-alphaProtein TransportAngiotensin IIAngiotensin II Type 1 Receptor BlockersAngiotensin II Type 2 Receptor Blockersbeta-ArrestinsCalciumMultiprotein ComplexesProtein Kinase C-alphaReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Sarcoplasmic Reticulum Calcium-Transporting ATPasesANG II-AT1R/AT2R complexANG II-AT1R/AT2R internalizationendoplasmic reticulumLLC-PK1 luminal membranesmicrotubule-dependent clathrin-independent endocytosis

Identifiers

PMID28468964
PMCPMC5582892
OpenAlexW2610165964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.