Evidence map›Paper›PMID 28468962›Full record

ArticleAmerican journal of physiology. Renal physiology2017

Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.

Eman Y Gohar, Malgorzata Kasztan, Bryan K Becker, Joshua S Speed, David M Pollock

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Sodium intake and biological sex influence urinary endothelin-1 in salt-resistant adults: a pilot study.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  2. Sex-Specific Differences in Kidney Function and Blood Pressure Regulation.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eman Y GoharCardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Malgorzata KasztanCardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Bryan K BeckerCardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Joshua S SpeedCardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
David M PollockCardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama dpollock@uab.edu.
University of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANANDA BASU · 2013 to 2026
$19.5M
MECHANISMS OF HYPERTENSION AND CARDIOVASCULAR DISEASEST32HL007457 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Martin E Young · 1985 to 2026
$8.6M
Endothelin - Mechanisms in Hypertension and ObesityK99HL127178 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SPEED, JOSHUA S · 2016 to 2017
$308k
NHLBI NIH HHS K99 HL127178NHLBI NIH HHS T32 HL007457NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

We recently reported that natriuresis produced by renal medullary salt loading is dependent on endothelin (ET)-1 and purinergic (P2) receptors in male rats. Because sex differences in ET-1 and P2 signaling have been reported, we decided to test whether ovarian sex hormones regulate renal medullary ET-1 and P2-dependent natriuresis. The effect of medullary NaCl loading on Na

Indexed as

NatriuresisOvariectomyRenal EliminationAnimalsEndothelin-1Endothelin Receptor AntagonistsFemaleKidney MedullaPurinergic P2 Receptor AgonistsPurinergic P2 Receptor AntagonistsRats, Sprague-DawleyReceptors, Purinergic P2Receptors, Purinergic P2Y2Signal TransductionSodiumSodium ChlorideEndothelin-1Endothelin Receptor AntagonistsP2ry2 protein, ratPurinergic P2 Receptor AgonistsPurinergic P2 Receptor Antagonistspurinoceptor P2Y4Receptors, Purinergic P2Receptors, Purinergic P2Y2SodiumSodium Chlorideendothelin-1purinergic receptorsrenal medullasodium excretion

Identifiers

PMID28468962
PMCPMC5582906
OpenAlexW2610396499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.