Evidence map›Paper›PMID 28468955›Full record

ArticleEMBO reports2017

Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4

Osamu Kaminuma, Kazufumi Katayama, Kimiko Inoue, Mayumi Saeki, Tomoe Nishimura, Noriko Kitamura, Yusuke Shimo, Soichi Tofukuji, Satoru Ishida, Narumi Ogonuki and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Role of CD4International journal of molecular sciences · 2020
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Osamu KaminumaAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan osamuk@yamanashi.ac.jp ogura@rtc.riken.go.jp.ORCID 0000-0003-1211-0410
Kazufumi KatayamaDrug Discovery & Disease Research Laboratory, SHIONOGI & Co., Ltd., Osaka, Japan.
Kimiko InoueBioresource Center RIKEN, Tsukuba, Japan.
Mayumi SaekiAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Tomoe NishimuraAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Noriko KitamuraAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yusuke ShimoDrug Discovery & Disease Research Laboratory, SHIONOGI & Co., Ltd., Osaka, Japan.
Soichi TofukujiDrug Discovery & Disease Research Laboratory, SHIONOGI & Co., Ltd., Osaka, Japan.
Satoru IshidaDrug Discovery & Disease Research Laboratory, SHIONOGI & Co., Ltd., Osaka, Japan.
Narumi OgonukiBioresource Center RIKEN, Tsukuba, Japan.
Satoshi KamimuraBioresource Center RIKEN, Tsukuba, Japan.
Mami OikawaBioresource Center RIKEN, Tsukuba, Japan.
Shigeki KatohDepartment of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Japan.
Akio MoriAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Michitaka ShichijoDrug Discovery & Disease Research Laboratory, SHIONOGI & Co., Ltd., Osaka, Japan.
Takachika HiroiAllergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Atsuo OguraBioresource Center RIKEN, Tsukuba, Japan osamuk@yamanashi.ac.jp ogura@rtc.riken.go.jp.
RIKEN BioResource Research Center · JPFutaba (Japan) · JPTokyo Metropolitan Institute of Medical Science · JPKawasaki Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T-cell receptor (TCR)-transgenic mice have been employed for evaluating antigen-response mechanisms, but their non-endogenous TCR might induce immune response differently than the physiologically expressed TCR Nuclear transfer cloning produces animals that retain the donor genotype in all tissues including germline and immune systems. Taking advantage of this feature, we generated cloned mice that carry endogenously rearranged TCR genes from antigen-specific CD4

Indexed as

Nuclear Transfer TechniquesAllelesAnimalsAntigensCD4-Positive T-LymphocytesCloning, OrganismDisease Models, AnimalHypersensitivityMiceMice, TransgenicReceptors, Antigen, T-CellAntigensReceptors, Antigen, T-CellallergyCD4+ T cellsomatic cell nuclear transferT‐cell receptor

Identifiers

PMID28468955
PMCPMC5452041
OpenAlexW2611959477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.