ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Sex-specific effects of stress on metabolic and cardiovascular disease: are women at higher risk?
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The relation between gallstone disease and cardiovascular disease.Scientific reports · 2017Pooled it
- Emotion dysregulation modulates the relation between emotional intensity and biological stress dysregulation among community women experiencing intimate partner violence.Psychoneuroendocrinology · 2025Article
- Inflammatory status along the brain-liver axis in animals vulnerable to prenatal stress: sex-related implications for stress-induced comorbidities.Translational psychiatry · 2025Article
- Stress across the lifecourse and adult mental and physical health outcomes.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Association of Occupational and Leisure-Time Physical Activity With Allostatic Load.American journal of preventive medicine · 2024Article
- Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024Review
- Cumulative Stress Across the Life Course and Biological Aging in Adulthood.Psychosomatic medicine · 2024Article
- Life's Essential 8, Genetic Susceptibility, and Incident Cardiovascular Disease: A Prospective Study.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- A 10-Year Cardiovascular Risk in Adults with Different Levels of Spiritual Health: Tehran Lipid and Glucose Study.Global heart · 2023Article
- Neurobiological Mechanisms Modulating Emotionality, Cognition and Reward-Related Behaviour in High-Fat Diet-Fed Rodents.International journal of molecular sciences · 2022Review
- Sex-Specific Catabolic Metabolism Alterations in the Critically Ill following High Dose Vitamin D.Metabolites · 2022Article
- Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS.Frontiers in immunology · 2022Article
- Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress.Biomedicines · 2021Review
- Effects of Somatic, Depression Symptoms, and Sedentary Time on Sleep Quality in Middle-Aged Women with Risk Factors for Cardiovascular Disease.Healthcare (Basel, Switzerland) · 2021Article
- Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats.Developmental psychobiology · 2021Article
- Stress, Social Support, and Resilience in Younger Rural Women: A Structural Equation Model.Healthcare (Basel, Switzerland) · 2021Article
- Metabolomic differences between critically Ill women and men.Scientific reports · 2021Article
- Article
- Evaluation of the Effectiveness of One- and Multi-Session Exposure-Based Treatments in Reducing Biological and Psychological Responses to Rat Phobia Among Students.Psychology research and behavior management · 2020Article
- Chronic variable stress alters hypothalamic-pituitary-adrenal axis function in the female mouse.Physiology & behavior · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular disease (CVD) has traditionally been viewed as a male disease; however, the relative risk for obesity and hypertension morbidity and mortality, major risk factors for CVD, is higher for women in the United States. Emerging epidemiological data strongly support stressful experiences as a modifiable risk factor for obesity, insulin resistance, and heart disease in women at all ages. Therefore, primary prevention of these diseases may be associated with both identifying and increasing the knowledge regarding the sex differences in emotional functioning associated with physiological responses to stress. The purpose of this review is to highlight the growing body of clinical and experimental studies showing that stress, obesity-associated metabolic disturbances, and CVD comorbidities are more prevalent in females. Overall, this review reveals the need for investigations to decipher the early origins of these comorbidities. Targeting the sources of behavioral/emotional stress through the trajectory of life has the potential to reduce the alarming projected rates for chronic disease in women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.