ArticleBlood2017
Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8
Open access · bronzeAbstract read
In one paragraph
Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 120 citations in OpenAlex.
- Clinical immunogenicity in rAAV gene therapy: Insights and implications.Molecular therapy. Advances · 2026Review
- Transient prophylactic immunosuppression with abatacept or dasatinib prevents immune responses in AAV gene transfer.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Taming immune responses to AAV gene therapy by programmed in vivo Treg expansion.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Strategies for Evading Cellular Immunity Against Recombinant AAV Vectors in Gene Therapy.Current medical science · 2026Review
- Deaths in gene therapy of Duchenne muscular dystrophy and other diseases: Underlying mechanisms and mitigating strategies.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Immunogenicity of Gene and Cell Therapies.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Gene Therapy for Heart Failure: Impact on Mitochondrial Dysfunction.Biomedicines · 2026Review
- Rewiring Dendritic Cell Immunity: The β-Catenin-TIM-3 Axis as a Target to Improve DC Cancer Vaccines.Cancers · 2026Review
- Current Status of Clinical Gene Therapy for Hemophilia and Globin Disorders.Journal of blood medicine · 2026Review
- Sterile inflammation in LHON: mitochondrial stress, innate immune signaling, and implications for AAV gene therapy.Frontiers in immunology · 2026Review
- Mechanisms of and mitigating strategies for cellular immune responses to CRISPR-associated nucleases in genome editing therapy.Frontiers in medicine · 2026Review
- Innate immune response to AAV-based gene therapy vectors: Mechanisms of complement activation and cytokine release.Molecular therapy. Methods & clinical development · 2025Article
- Can Sex-based Variations in the Immune Responses to AAV Gene Therapy Affect Safety and Efficacy? A Review of Current Understanding.The AAPS journal · 2025Review
- Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1.PLoS pathogens · 2025Article
- Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products.Investigative ophthalmology & visual science · 2025Article
- Dynamic changes in immune cell subsets in blood and lymph node over the course of acute HIV infection.Journal of virus eradication · 2025Article
- The curious case of AAV immunology.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Gene therapy for hemophilia - From basic science to first approvals of "one-and-done" therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain.Nature communications · 2025Article
- Impact of liver fibrosis on AAV-mediated gene transfer to mouse hepatocytes.Nature communications · 2025Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Geoffrey L RogersDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
Jamie L ShirleyDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
Irene ZolotukhinDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
Sandeep R P KumarDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
Alexandra ShermanDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
George Q PerrinDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
Brad E HoffmanDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
Arun SrivastavaDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
Etiena Basner-TschakarjanCenter of Molecular and Cellular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA.
Mark A WalletDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL; and.
Cox TerhorstDivision of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Moanaro BiswasDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
Roland W HerzogDepartment of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL.
University of Florida · USBeth Israel Deaconess Medical Center · USChildren's Hospital of Philadelphia · US
Funding
Enhancing immune regulation in gene therapy for hemophiliaR01HL131093 · NHLBI · UNIVERSITY OF FLORIDA · PI Ype Peter De Jong, Roland W. Herzog · 2016 to 2026
$7.2MImmunology of Factor IX Gene Transfer to LiverR01AI051390 · NIAID · UNIVERSITY OF FLORIDA · PI HERZOG, ROLAND W. · 2002 to 2022
$6.7MNext Generation of Recombinant AAV Serotype Vectors for Gene TherapyR01HL097088 · NHLBI · UNIVERSITY OF FLORIDA · PI GAO, GUANGPING, HERZOG, ROLAND W. · 2010 to 2018
$5.4MBASIC MICROBIOLOGY &INFECTIOUS DISEASEST32AI007110 · NIAID · UNIVERSITY OF FLORIDA · PI Stephanie M Karst · 1985 to 2026
$4.3MGenetic Regulation of Human Beta Cell DestructionUC4DK104194 · NIDDK · UNIVERSITY OF FLORIDA · PI MATHEWS, CLAYTON E · 2014 to 2014
$3.1MNHLBI NIH HHS R01 HL097088NHLBI NIH HHS R01 HL131093NIAID NIH HHS R01 AI051390NIAID NIH HHS T32 AI007110NIDDK NIH HHS UC4 DK104194
Abstract
Adeno-associated virus (AAV) is a replication-deficient parvovirus that is extensively used as a gene therapy vector. CD8
Indexed as
Lymphocyte ActivationAnimalsCapsid ProteinsCD8-Positive T-LymphocytesDendritic CellsDependovirusGenetic TherapyMiceMice, KnockoutMyeloid Differentiation Factor 88Plasma CellsToll-Like Receptor 9Capsid ProteinsMyd88 protein, mouseMyeloid Differentiation Factor 88Tlr9 protein, mouseToll-Like Receptor 9
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.