ArticleJournal of the American Heart Association2017
Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS.PloS one · 2019Trial
- Current Advancements in the Diagnosis and Management of Mild-to-moderate Coronary Stenosis.Reviews in cardiovascular medicine · 2025Review
- Gender Disparities in Ischemic Heart Disease Management: Underdiagnosis in Women and Differences in Treatment.Cureus · 2025Review
- Acute coronary syndromes: mechanisms, challenges, and new opportunities.European heart journal · 2025Review
- Shear Stress Induces a Time-Dependent Inflammatory Response in Human Monocyte-Derived Macrophages.Annals of biomedical engineering · 2024Article
- Endothelial Shear Stress Metrics Associate With Proinflammatory Pathways at the Culprit Site of Coronary Erosion.JACC. Basic to translational science · 2024Article
- Precision Medicine in Acute Coronary Syndromes.Journal of clinical medicine · 2024Review
- Implications for neutrophils in cardiac arrhythmias.American journal of physiology. Heart and circulatory physiology · 2024Review
- Prognostic value of Geriatric Nutritional Risk Index and systemic immune-inflammatory index in elderly patients with acute coronary syndromes.Scientific reports · 2024Article
- New Concepts on the Pathophysiology of Acute Coronary Syndrome.Reviews in cardiovascular medicine · 2023Review
- Culprit Lesion Morphology on Optical Coherence Tomography in ST-elevation Myocardial Infarction vs Non ST-elevation Myocardial Infarction - A Systematic Review of 7526 Patients.Journal of the Saudi Heart Association · 2023Review
- Systemic Immune-Inflammation Index Predicts Major Cardiovascular Adverse Events in Patients with ST-Segment Elevated Myocardial Infarction.Arquivos brasileiros de cardiologia · 2022Observational
- Antithrombotic Therapy: Prevention and Treatment of Atherosclerosis and Atherothrombosis.Handbook of experimental pharmacology · 2022Article
- Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions.Nature reviews. Cardiology · 2021Review
- Atherothrombosis in Acute Coronary Syndromes-From Mechanistic Insights to Targeted Therapies.Cells · 2021Review
- Angiotensin-converting enzyme 2: a double-edged sword in COVID-19 patients with an increased risk of heart failure.Heart failure reviews · 2021Review
- Plaque Erosion: A Distinctive Pathological Mechanism of Acute Coronary Syndrome.Frontiers in cardiovascular medicine · 2021Review
- High Plasma Myeloperoxidase Is Associated with Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction.Journal of cardiovascular translational research · 2020Article
- The Role of Natural Killer (NK) Cells in Acute Coronary Syndrome: A Comprehensive Review.Biomolecules · 2020Review
- Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.European heart journal · 2020Observational
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlaque erosion causes 30% of ST-segment elevation myocardial infarctions, but the underlying cause is unknown. Inflammatory infiltrates are less abundant in erosion compared with rupture in autopsy studies. We hypothesized that erosion and rupture are associated with significant differences in intracoronary cytokines in vivo. METHODS AND
resultsForty ST-segment elevation myocardial infarction patients with <6 hours of chest pain were classified as ruptured fibrous cap (RFC) or intact fibrous cap (IFC) using optical coherence tomography. Plasma samples from the infarct-related artery and a peripheral artery were analyzed for expression of 102 cytokines using arrays; results were confirmed with ELISA. Thrombectomy samples were analyzed for differential mRNA expression using quantitative real-time polymerase chain reaction. Twenty-three lesions were classified as RFC (58%), 15 as IFC (38%), and 2 were undefined (4%). In addition, 12% (12 of 102) of cytokines were differentially expressed in both coronary and peripheral plasma. I-TAC was preferentially expressed in RFC (significance analysis of microarrays adjusted
conclusionsThese results demonstrate differential intracoronary cytokine expression in RFC and IFC. Elevated thrombospondin 1 and epidermal growth factor may play an etiological role in erosion.
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