ArticleBMC complementary and alternative medicine2017
Punica granatum peel extracts: HPLC fractionation and LC MS analysis to quest compounds having activity against multidrug resistant bacteria.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
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- Pharmacological activities and gas chromatography-mass spectrometry analysis for the identification of bioactive compounds fromFrontiers in pharmacology · 2022Article
- Green Veterinary Pharmacology Applied to Parasite Control: Evaluation ofVeterinary sciences · 2021Article
- Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CClBMC complementary medicine and therapies · 2021Article
- A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Antifungal, Antitumoral and Antioxidant Potential of the Danube DeltaAntibiotics (Basel, Switzerland) · 2019Article
- A promising growth promoting Meyerozyma caribbica from Solanum xanthocarpum alleviated stress in maize plants.Bioscience reports · 2019Article
- Anti-infective potential of hydroalcoholic extract ofF1000Research · 2019Article
- Chemical composition, antioxidant and hepatoprotective activities of methanol extracts from leaves ofPeerJ · 2019Article
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14 authors.
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Abstract
backgroundMedicinal plants are rich source of traditional herbal medicine around the globe. Most of the plant's therapeutic properties are due to the presence of secondary bioactive compounds.
methodsThe present study analyzed the High Pressure Liquid Chromatography (HPLC) fractions of Puncia granatum (peel) extracts (aqueous, chloroform, ethanol and hexane) against multidrug resistant bacterial pathogens (Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus). All the fractions having antibacterial activity was processed for bioactive compounds identification using LC MS/MS analysis.
resultsAmong total HPLC fractions (n = 30), 4 HPLC fractions of P. granatum (peel) showed potential activity against MDR pathogens. Fraction 1 (F1) and fraction 4 (F4) collected from aqueous extract showed maximum activity against P. aeruginosa. Fraction 2 (F2) of hexane showed antibacterial activity against three pathogens, while ethanol F4 exhibited antibacterial activity against A. baumannii. The active fractions were processed for LC MS/MS analysis to identify bioactive compounds. Valoneic acid dilactone (aqueous F1 and F4), Hexoside (ethanol F4) and Coumaric acid (hexane F2) were identified as bioactive compounds in HPLC fractions.
conclusionPuncia granatum peel extracts HPLC fractions exhibited potential inhibitory activity against MDR bacterial human pathogens. Several bioactive compounds were identified from the HPLC fractions. Further characterization of these compounds may be helpful to conclude it as therapeutic lead molecules against MDR pathogens.
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