ArticleInternational journal of molecular sciences2017
Clock Genes and Altered Sleep-Wake Rhythms: Their Role in the Development of Psychiatric Disorders.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05413486 (Circadian Disturbances in People With Mental Disease), which is not on this map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Circadian Disturbances in People With Mental Disease
Who cites it
67 citing papers in PubMed, 183 citations in OpenAlex.
- Comparison of Clonazepam and Tongue Protector in the Treatment of Burning Mouth Syndrome.International journal of environmental research and public health · 2022Trial
- Validation of the English version of the Mood Rhythm Instrument.BMC psychology · 2020Trial
- Sleep disturbances as early indicators of incident psychiatric disease.European archives of psychiatry and clinical neuroscience · 2026Article
- Genetic evidence linking circadian rhythm genes and hypertension: A two-sample Mendelian randomization study.The Journal of international medical research · 2026Article
- Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability.bioRxiv : the preprint server for biology · 2026Article
- Causal relationship between tinnitus and 8 psychiatric phenotypes: a Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Unlocking Unique Physiological Reactions: Novel Insights into Four Cerebral and Systemic Physiological Responses to Colored Light.Advances in experimental medicine and biology · 2026Article
- Regular sleep patterns, not just duration, critical for mental health: association of accelerometer-derived sleep regularity with incident depression and anxiety.Psychological medicine · 2025Article
- Circadian attributes of neurological and psychiatric disorders as basis for their medication chronotherapy.Advanced drug delivery reviews · 2025Review
- The mediating effects of sleep quality in the relationship between loneliness and depression among middle-aged and older adults.Scientific reports · 2025Article
- Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning.Discover oncology · 2025Article
- Altered Rhythmicity, Depressive Ruminative Thinking and Suicidal Ideation as Possible Correlates of an Unrecognized Autism Spectrum in Patients with Borderline Personality Disorder.Brain sciences · 2024Article
- Optimizing Chronotherapy in Psychiatric Care: The Impact of Circadian Rhythms on Medication Timing and Efficacy.Clocks & sleep · 2024Review
- Sleep Problems and Autism Impairments in a Large Community Sample of Children and Adolescents.Child psychiatry and human development · 2024Article
- TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex.iScience · 2024Article
- High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models.iScience · 2024Article
- Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HDAC3-Bmal1/clock interruption.CNS neuroscience & therapeutics · 2024Article
- Association between Shift Work and Health Outcomes in the General Population in China: A Cross-Sectional Study.Brain sciences · 2024Article
- Early growth response 1 (EGR1) is downregulated in peripheral blood from patients with major psychiatric disorders.Trends in psychiatry and psychotherapy · 2024Article
- Circadian Rhythms and Sleep Disorders Associated to Major Depressive Disorder: Pathophysiology and Therapeutic Opportunities.CNS & neurological disorders drug targets · 2024Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, the circadian clocks network (central and peripheral oscillators) controls circadian rhythms and orchestrates the expression of a range of downstream genes, allowing the organism to anticipate and adapt to environmental changes. Beyond their role in circadian rhythms, several studies have highlighted that circadian clock genes may have a more widespread physiological effect on cognition, mood, and reward-related behaviors. Furthermore, single nucleotide polymorphisms in core circadian clock genes have been associated with psychiatric disorders (such as autism spectrum disorder, schizophrenia, anxiety disorders, major depressive disorder, bipolar disorder, and attention deficit hyperactivity disorder). However, the underlying mechanisms of these associations remain to be ascertained and the cause-effect relationships are not clearly established. The objective of this article is to clarify the role of clock genes and altered sleep-wake rhythms in the development of psychiatric disorders (sleep problems are often observed at early onset of psychiatric disorders). First, the molecular mechanisms of circadian rhythms are described. Then, the relationships between disrupted circadian rhythms, including sleep-wake rhythms, and psychiatric disorders are discussed. Further research may open interesting perspectives with promising avenues for early detection and therapeutic intervention in psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.