Evidence map›Paper›PMID 28467917›Full record

SynthesisCortex; a journal devoted to the study of the nervous system and behavior2017

Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis.

Masoud Tahmasian, Simon B Eickhoff, Kathrin Giehl, Frank Schwartz, Damian M Herz, Alexander Drzezga, Thilo van Eimeren, Angela R Laird, Peter T Fox, Habibolah Khazaie and 3 more

Open access · greenAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cortex; a journal devoted to the study of the nervous system and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 12 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 12 syntheses or guidelines pooled it, 129 citations in OpenAlex.

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  18. Zero-shot medical event prediction using a generative pretrained transformer on electronic health records.Journal of the American Medical Informatics Association : JAMIA · 2025
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Masoud TahmasianDepartment of Neurology, University Hospital Cologne, Germany; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany; Institute of Medical Sciences and Technology, Shahid Beheshti University, Tehran, Iran; Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran. Electronic address: masoudtahmasian@gmail.com.
Simon B EickhoffInstitute of Clinical Neuroscience & Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1, INM-7), Research Center Jülich, Jülich, Germany.
Kathrin GiehlDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
Frank SchwartzDepartment of Neurology, University Hospital Cologne, Germany.
Damian M HerzMedical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Alexander DrzezgaDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
Thilo van EimerenDepartment of Neurology, University Hospital Cologne, Germany; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
Angela R LairdDepartment of Physics, Florida International University, Miami, FL, USA.
Peter T FoxResearch Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA; South Texas Veterans Health Care System, San Antonio, TX, USA.
Habibolah KhazaieSleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran.
Mojtaba ZareiInstitute of Medical Sciences and Technology, Shahid Beheshti University, Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Carsten EggersDepartment of Neurology, University Hospital Cologne, Germany; Department of Neurology, Phillips University Marburg, Germany.
Claudia R EickhoffInstitute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Aachen, Germany.
University Hospital Cologne · DEKermanshah University of Medical Sciences · IRFlorida International University · USForschungszentrum Jülich · DEHeinrich Heine University Düsseldorf · DEInstitute for Research in Fundamental Sciences · IRJohn Radcliffe Hospital · GBPhilipps University of Marburg · DEThe University of Texas Health Science Center at San Antonio · US

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
NIMH NIH HHS R01 MH074457
6 · The paper itself

Abstract

Parkinson's disease (PD) is a common progressive neurodegenerative disorder. Studies using resting-state functional magnetic resonance imaging (fMRI) to investigate underlying pathophysiology of motor and non-motor symptoms in PD yielded largely inconsistent results. This quantitative neuroimaging meta-analysis aims to identify consistent abnormal intrinsic functional patterns in PD across studies. We used PubMed to retrieve suitable resting-state studies and stereotactic data were extracted from 28 individual between-group comparisons. Convergence across their findings was tested using the activation likelihood estimation (ALE) approach. We found convergent evidence for intrinsic functional disturbances in bilateral inferior parietal lobule (IPL) and the supramarginal gyrus in PD patients compared to healthy subjects. In follow-up task-based and task-independent functional connectivity (FC) analyses using two independent healthy subject data sets, we found that the regions showing convergent aberrations in PD formed an interconnected network mainly with the default mode network (DMN). Behavioral characterization of these regions using the BrainMap database suggested associated dysfunction of perception and executive processes. Taken together, our findings highlight the role of parietal cortex in the pathophysiology of PD.

Indexed as

Brain MappingLikelihood FunctionsNeuroimagingBrainHumansMagnetic Resonance ImagingParkinson DiseaseALE meta-analysisDefault mode networkInferior parietal lobuleResting-state fMRI

Identifiers

PMID28467917
PMCPMC8005854
OpenAlexW2604719927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.