ArticleCell reports2017
The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Topological analysis of neuronal assemblies reveals low-rank structure modulated by cholinergic activity.bioRxiv : the preprint server for biology · 2025Article
- Label-Free Multiphoton Imaging Reveals Volumetric Shifts Across Development in Sensory-Related Brain Regions of a Miniature Transparent Vertebrate.The Journal of comparative neurology · 2025Article
- Decreased GABA levels during development result in increased connectivity in the larval zebrafish tectum.bioRxiv : the preprint server for biology · 2024Article
- Article
- Functional neuronal circuits emerge in the absence of developmental activity.Nature communications · 2024Article
- Facemap: a framework for modeling neural activity based on orofacial tracking.Nature neuroscience · 2024Article
- Radial astrocyte synchronization modulates the visual system during behavioral-state transitions.Neuron · 2023Article
- Piezo1-mediated spontaneous calcium transients in satellite glia impact dorsal root ganglia development.PLoS biology · 2023Article
- Behavioral analysis through the lifespan ofiScience · 2023Article
- Thalamic regulation of a visual critical period and motor behavior.Cell reports · 2023Article
- Purely STDP-based assembly dynamics: Stability, learning, overlaps, drift and aging.PLoS computational biology · 2023Article
- Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish.Scientific reports · 2022Article
- High activity and high functional connectivity are mutually exclusive in resting state zebrafish and human brains.BMC biology · 2022Article
- Single-Cell RNA Sequencing Characterizes the Molecular Heterogeneity of the Larval Zebrafish Optic Tectum.Frontiers in molecular neuroscience · 2022Article
- Drifting assemblies for persistent memory: Neuron transitions and unsupervised compensation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Defective Neuronal Positioning Correlates With Aberrant Motor Circuit Function in Zebrafish.Frontiers in neural circuits · 2021Article
- Model-based decoupling of evoked and spontaneous neural activity in calcium imaging data.PLoS computational biology · 2020Article
- Article
- Autonomous emergence of connectivity assemblies via spike triplet interactions.PLoS computational biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emergence of these patterns during development nor the role of retinal inputs in their maturation has been characterized. Using two-photon calcium imaging, we analyzed spontaneous activity in intact and enucleated zebrafish larvae throughout tectum development. At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity. Although the absence of retinal inputs had a significant impact on the development of the temporal structure, the tectum was still capable of developing a spatial structure associated with the circuit's functional roles and predictive of behavior. We conclude that neither visual experience nor intrinsic retinal activity is essential for the emergence of a spatially structured functional circuit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.