ArticleNature2017
Maintenance of persistent activity in a frontal thalamocortical loop.
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 304 papers.
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Who cites it
304 citing papers in PubMed, 584 citations in OpenAlex.
- Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake.Scientific reports · 2021Trial
- Thalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction.Science advances · 2026Article
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Reciprocal connections dynamically build consensus between neocortical areas.Nature neuroscience · 2026Article
- Inter-regional interactions uncouple within-region inhibition stabilization and paradoxical responses.bioRxiv : the preprint server for biology · 2026Article
- Lipid Activation of a Thalamic GPCR Extends Working Memory Time-scales.bioRxiv : the preprint server for biology · 2026Article
- Decoding behavior with minimal and interpretable agent models.PLoS computational biology · 2026Article
- Condition-Dependent Noise Correlations without Condition-Dependent Spike Counts.bioRxiv : the preprint server for biology · 2026Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Anterior lateral motor cortex enables contextual decision-making via dynamic reconfiguration of local circuits.Cell reports · 2026Article
- Single-cell reconstruction of whole-brain efferent projections from mouse ventral posteromedial thalamus.Brain informatics · 2026Article
- Tuft dendrite spikes are accompanied by selective input from distinct functional networks.bioRxiv : the preprint server for biology · 2026Article
- A computational architecture incorporating shallow brain networks: integrating parallel cortical and subcortical processing.Current research in neurobiology · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- A scalable hippocampal code for flexible interval timing through persistent activity.bioRxiv : the preprint server for biology · 2026Article
- A comparison of movement-related neuronal activities in cerebellar- and basal ganglia-recipient regions of the macaque thalamus.bioRxiv : the preprint server for biology · 2026Article
- Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026Article
- Functional reorganization of motor cortex connectivity during learning.bioRxiv : the preprint server for biology · 2026Article
- Corticothalamic communication for action coordination in a skilled motor behavior.Nature neuroscience · 2026Article
- Motor working memory.Trends in cognitive sciences · 2026Review
244 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Persistent neural activity maintains information that connects past and future events. Models of persistent activity often invoke reverberations within local cortical circuits, but long-range circuits could also contribute. Neurons in the mouse anterior lateral motor cortex (ALM) have been shown to have selective persistent activity that instructs future actions. The ALM is connected bidirectionally with parts of the thalamus, including the ventral medial and ventral anterior-lateral nuclei. We recorded spikes from the ALM and thalamus during tactile discrimination with a delayed directional response. Here we show that, similar to ALM neurons, thalamic neurons exhibited selective persistent delay activity that predicted movement direction. Unilateral photoinhibition of delay activity in the ALM or thalamus produced contralesional neglect. Photoinhibition of the thalamus caused a short-latency and near-complete collapse of ALM activity. Similarly, photoinhibition of the ALM diminished thalamic activity. Our results show that the thalamus is a circuit hub in motor preparation and suggest that persistent activity requires reciprocal excitation across multiple brain areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.