ArticlePloS one2017
Urinary metals in a spontaneous canine model of calcium oxalate urolithiasis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- A urinary proteomic study in hypercalciuric dogs with and without calcium oxalate urolithiasis.Veterinary world · 2022Article
- The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs.Journal of veterinary internal medicine · 2021Article
- Urolithiasis in dogs: Evaluation of trends in urolith composition and risk factors (2006-2018).Journal of veterinary internal medicine · 2021Article
- Bone resorption in dogs with calcium oxalate urolithiasis and idiopathic hypercalciuria.Research in veterinary science · 2019Article
- Vitamin D metabolism in dogs with and without hypercalciuric calcium oxalate urolithiasis.Journal of veterinary internal medicine · 2019Article
- Estimates of Urinary Calcium Excretion in Dogs With and Without Calcium Oxalate Urolithiasis.Journal of veterinary internal medicineArticle
- Association of Diet and Calcium Tartrate Tetrahydrate Uroliths in Dogs.Journal of veterinary internal medicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Calcium oxalate urolithiasis is a common and painful condition in people. The pathogenesis of this disease is complex and poorly understood. Laboratory animal and in vitro studies have demonstrated an effect of multiple trace metals in the crystallization process, and studies in humans have reported relationships between urinary metal concentrations and stone risk. Dogs are a spontaneous model of calcium oxalate urolithiasis, and the metal content of canine calcium oxalate stones mirrors that of human stones. The aim of this study was to test for a relationship between urinary metals and calcium oxalate urolithiasis in dogs. We hypothesized that urinary metals would differ between dogs with and without calcium oxalate urolithiasis. Urine from 122 dogs (71 cases and 51 stone-free controls) was analyzed for calcium and 12 other metals. The cases had higher urinary calcium, copper, iron, and vanadium and lower urinary cobalt. Higher urinary vanadium in the cases was associated with being fed a therapeutic stone-prevention diet. Urinary calcium had a strong positive correlation with strontium and moderate positive correlations with chromium, nickel, and zinc. The results of this study complement the findings of similar human studies and suggest a potential role of trace metals in calcium oxalate urolithiasis. Further investigation into how trace metals may affect stone formation is warranted.
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Registered trials
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