ArticlePloS one2017
Biochemical markers of bone turnover in benign paroxysmal positional vertigo.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Association between vitamin D, vitamin D supplementation and benign paroxysmal positional vertigo: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Pooled it
- Association between bone mineral density and benign paroxysmal positional vertigo: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Pooled it
- Altered auditory and vestibular functioning in individuals with low bone mineral density: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Pooled it
- Randomized Controlled Trial Assessing Vitamin D's Role in Reducing BPPV Recurrence in Older Adults.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Trial
- The Impact of Vitamin D Deficiency and Osteoporosis on Benign Paroxysmal Positional Vertigo Recurrence: A Population-Based Study From the Korean National Health Insurance Service.Journal of Korean medical science · 2026Article
- Prediction of benign paroxysmal positional vertigo recurrence in postmenopausal women: a machine learning-based clinical study.Frontiers in neurology · 2026Article
- Effect of calcium and vitamin D supplementation on recurrence of benign paroxysmal positional vertigo in osteoporotic patients.American journal of translational research · 2026Article
- Otolith Deterioration: Factors Affecting Microvascular and Structural Integrity.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Investigation of Serum Calcium and Vitamin D Levels in Patients with Refractory Benign Paroxysmal Positional Vertigo.Turkish archives of otorhinolaryngology · 2025Article
- Assessment of hearing and balance functions in patients with acromegaly by the use of an audiovestibular test battery: a cross-sectional study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- A minimal ion-chemistry model for predicting benign paroxysmal positional vertigo risk based on endolymphatic calcium and pH.Frontiers in neurology · 2025Article
- Do Patients with Benign Paroxysmal Positional Vertigo Have a Higher Prevalence of Osteoporosis? A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2024Review
- Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study.Journal of otology · 2023Article
- Effect of hormonal therapy on the otoconial changes caused by estrogen deficiency.Scientific reports · 2022Article
- Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study.Frontiers in neurology · 2022Article
- Lower Serum Irisin Levels Are Associated with Increased Osteoporosis and Oxidative Stress in Postmenopausal.Reports of biochemistry & molecular biology · 2021Article
- Risk factors for residual dizziness in patients successfully treated for unilateral benign posterior semicircular canal paroxysmal positional vertigo.The Journal of international medical research · 2020Article
- Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment.The journal of physiological sciences : JPS · 2020Review
- Probable benign paroxysmal positional vertigo, spontaneously resolved: Incidence in medical practice, patients' characteristics and the natural course.Journal of otology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSeveral studies have suggested a possible relationship between recurrent benign paroxysmal positional vertigo (BPPV) and altered calcium homeostasis in the endolymph of the inner ear. The present study aimed to evaluate the association between Ca2+ and vitamin D status and BPPV occurrence as well as the status of bone biochemical markers in osteoporotic patients who were diagnosed with idiopathic BPPV.
methodsThe study included total 132 patients who were referred to our clinic between August 2008 and October 2013. Based on the bone mineral density (BMD) results, the subjects were divided into three groups: normal BMD (n = 34), osteopenia (n = 40) and osteoporosis (n = 58). The biochemical markers of bone turnover including serum Carboxy-terminal telopeptide of type I collagen (s-CTX), osteocalcin, alkaline phosphatase (ALP) and urinary free deoxypyridinoline (u-DPD), were analyzed, along with the serum Ca2+ and vitamin D levels.
resultsThe mean serum calcium, phosphate and creatinine clearance levels were within the standard laboratory reference range. The incidence of vitamin D deficiency was 11.8% (4/34) in the normal BMD group, 15% (6/40) in the osteopenia group and 43.1% (25/58) in the osteoporosis group. There was a positive correlation between the 25(OH)D and BMD results in the patients with BPPV. Among the bone turnover markers, the osteocalcin and u-DPD levels were significantly elevated in the osteoporotic patients with BPPV. Multiple logistic regression analyses showed that osteoporosis and vitamin D deficiency were associated with BPPV.
conclusionOur findings suggest that the prevalence of BPPV in osteoporotic patients is associated with vitamin D deficiency and high bone turnover rates at systemic level, which could disturb local Ca2+ homeostasis in the inner ear.
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