ArticlePloS one2017
Linalool prevents oxidative stress activated protein kinases in single UVB-exposed human skin cells.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 106 citations in OpenAlex.
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- Protective effect of young coconut water on MMP -1 levels and collagen fiber thickness in male Wistar rats exposed to UVB light exposure.Open veterinary journal · 2026Article
- Farrerol mitigates lipopolysaccharide-induced acute lung injury through dual regulation of oxidative stress and inflammation via Nrf2 pathway.Open life sciences · 2026Article
- Correlations between Aging, Telomeres, and Natural Compounds.Aging and disease · 2025Review
- Pisco, an Appellation of Origin from Peru: A review.Heliyon · 2025Review
- Mechanistic insights into clary sage oils role in wound healing: targeting oxidative stress and inflammatory pathways.Frontiers in pharmacology · 2025Article
- Atractylodin mitigates UVB radiation-induced oxidative stress and photoaging responses by enhancing NrF2 signaling in human epidermal keratinocytes.Archives of dermatological research · 2024Article
- Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic.Biomolecules · 2024Review
- Linalool exerts antioxidant activity in a rat model of diabetes by increasing catalase activity without antihyperglycemic effect.Experimental and therapeutic medicine · 2024Article
- Monoterpene linalool restrains gentamicin-mediated acute kidney injury in rats by subsiding oxidative stress, apoptosis, and the NF-κB/iNOS/TNF-α/IL-1β pathway and regulating TGF-β.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Analysing the Antibacterial Synergistic Interactions of Romanian Lavender Essential Oils via Gas Chromatography-Mass Spectrometry: In Vitro and In Silico Approaches.Plants (Basel, Switzerland) · 2024Article
- Linalool and Geraniol Defend Neurons from Oxidative Stress, Inflammation, and Iron Accumulation in In Vitro Parkinson's Models.Antioxidants (Basel, Switzerland) · 2024Article
- Medicinal Anti-Inflammatory Patch Loaded with Lavender Essential Oil.International journal of molecular sciences · 2024Article
- Influence of chlorpyrifos exposure on UVB irradiation induced toxicity in human skin cells.Journal of occupational medicine and toxicology (London, England) · 2023Article
- Cytogenetic Studies on Genoprotective Effect ofLife (Basel, Switzerland) · 2023Article
- Improvement in Skin Penetration Capacity of Linalool by Using Microemulsion as a Delivery Carrier: Formulation Optimization and In Vitro Evaluation.Pharmaceutics · 2023Article
- Computational Studies Applied to Linalool and Citronellal Derivatives Against Alzheimer's and Parkinson's Disorders: A Review with Experimental Approach.Current neuropharmacology · 2023Review
- Article
- Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase-3 and caspase-9 during apoptosis.Food science & nutrition · 2023Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet-B radiation (285-320 nm) elicits a number of cellular signaling elements. We investigated the preventive effect of linalool, a natural monoterpene, against UVB-induced oxidative imbalance, activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling in HDFa cells. We observed that linalool treatment (30 μM) prevented acute UVB-irradiation (20 mJ/cm2) mediated loss of activities of antioxidant enzymes in HDFa cells. The comet assay results illustrate that linalool significantly prevents UVB-mediated 8-deoxy guanosine formation (oxidative DNA damage) rather than UVB-induced cyclobutane pyrimidine (CPD) formation. This might be due to its ability to prevent UVB-induced ROS formation and to restore the oxidative imbalance of cells. This has been reflected in UVB-induced overexpression of MAPK and NF-κB signaling. We observed that linalool inhibited UVB-induced phosphorylation of ERK1, JNK and p38 proteins of MAPK family. Linalool inhibited UVB-induced activation of NF-κB/p65 by activating IκBa. We further observed that UVB-induced expression of TNF-α, IL6, IL-10, MMP-2 and MMP-9 was modulated by linalool treatment in HDFa cells. Thus, linalool protects the human skin cells from the oxidative damages of UVB radiation and modulates MAPK and NF-κB signaling in HDFa cells. The present findings substantiate that linalool may act as a photoprotective agent against UVB-induced skin damages.
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