ArticleeLife2017
TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Oncogenic and tumor-suppressive roles of Lipocalin 2 (LCN2) in tumor progression.Oncology research · 2025Review
- Microfibril-associated protein 2 interacts with LEF1/TCF7 and immune infiltration in uterine corpus endometrial carcinoma.Central-European journal of immunology · 2025Article
- TCF7L1 regulates colorectal cancer cell migration by repressing GAS1 expression.Scientific reports · 2024Article
- Biomarker potential of the LEF1/TCF family members in breast cancer: Bioinformatic investigation on expression and clinical significance.Genetics and molecular biology · 2023Article
- Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A.Nature communications · 2022Article
- Competing endogenous RNA networks related to prognosis in chronic lymphocytic leukemia: comprehensive analyses and construction of a novel risk score model.Biomarker research · 2022Article
- Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma.Molecular cancer · 2022Article
- Lipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis.Journal of inflammation research · 2022Review
- SUV39H2 epigenetic silencing controls fate conversion of epidermal stem and progenitor cells.The Journal of cell biology · 2021Article
- Identification of Transcription Factor-Related Gene Signature and Risk Score Model for Colon Adenocarcinoma.Frontiers in genetics · 2021Article
- Wnt Signaling Pathways in Keratinocyte Carcinomas.Cancers · 2019Review
- TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.Acta biochimica et biophysica Sinica · 2019Article
- Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells.Stem cell research & therapy · 2018Article
- A meta-analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma.Oncology letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Amy T KuStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Timothy M ShaverStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Ajay S RaoStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Jeffrey M HowardStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Christine N RodriguezStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Qi MiaoStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Gloria GarciaStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Diep LeStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Diane YangStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Malgorzata BorowiakStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Daniel N CohenDepartment of Pathology and Immunology, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, United States.
Vida ChitsazzadehDepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, United States.
Abdul H DiwanDepartment of Dermatology, Baylor College of Medicine, Houston, United States.
Kenneth Y TsaiDepartment of Tumor Biology, Moffitt Cancer Center, Tampa, United States.
Hoang NguyenStem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-1091-7483
Baylor College of Medicine · USMichael E. DeBakey VA Medical Center · USMoffitt Cancer Center · USThe University of Texas MD Anderson Cancer Center · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MVirology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7MTraining In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9MTraining Program in Translational Biology and Molecular MedicineT32GM088129 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROONEY, CLIONA M., VAN DEN VEYVER, IGNATIA B · 2010 to 2019
$3.0M(PQA4) Molecularly Targeted Chemoprevention for Preneoplastic Squamous EpitheliaR01CA194617 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI TSAI, KENNETH Y · 2015 to 2018
$1.7MMicroRNA Targets for Chemoprevention of Squamous Cell Carcinoma (R01 CA194062-01A1)R01CA194062 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI TSAI, KENNETH Y · 2016 to 2020
$1.6MBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kNCI NIH HHS P30 CA016672NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA194062NCI NIH HHS R01 CA194617NCRR NIH HHS S10 RR024574NHLBI NIH HHS T32 HL092332NIAID NIH HHS P30 AI036211NIGMS NIH HHS T32 GM088129
Abstract
The transcription factor
Indexed as
CarcinogenesisAnimalsbeta CateninCarcinoma, Squamous CellDisease Models, AnimalGene Expression ProfilingHeterograftsHumansLipocalin-2MiceSkin NeoplasmsTranscription Factor 7-Like 1 Proteinbeta CateninCTNNB1 protein, humanLCN2 protein, humanLipocalin-2TCF7L1 protein, humanTranscription Factor 7-Like 1 Proteincancer biologycell biologycell migrationhumanmouseoncogene-induced senescenceskin squamous cell carcinomaTCF7L1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.