ArticleArchives of pathology & laboratory medicine2017
Interstitial Pneumonia With Autoimmune Features: Value of Histopathology.
Article in Archives of pathology & laboratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review and meta-analysis of the prognosis and prognostic factors of interstitial pneumonia with autoimmune features.BMJ open · 2019Pooled it
- State of the art in interstitial pneumonia with autoimmune features: a systematic review on retrospective studies and suggestions for further advances.European respiratory review : an official journal of the European Respiratory Society · 2018Pooled it
- Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma.Internal medicine (Tokyo, Japan) · 2024Article
- Interstitial Pneumonia with Autoimmune Features: Aiming to Define, Refine, and Treat.Revista colombiana de reumatologia · 2024Article
- Automated machine learning for the identification of asymptomatic COVID-19 carriers based on chest CT images.BMC medical imaging · 2024Article
- Clinical Characterization and Predictive Factors for Progression in a Cohort of Patients with Interstitial Lung Disease and Features of Autoimmunity: The Need for a Revision of IPAF Classification Criteria.Medicina (Kaunas, Lithuania) · 2023Article
- Fine-tuning characterization of patients with interstitial pneumonia and an underlying autoimmune disease in real-world practice: We get closer with Nailfold videocapillaroscopy.Frontiers in medicine · 2023Article
- Interstitial Pneumonia with Autoimmune Features: What the Rheumatologist Needs to Know.Current rheumatology reports · 2022Review
- Clinical diagnosis of patients subjected to surgical lung biopsy with a probable usual interstitial pneumonia pattern on high-resolution computed tomography.BMC pulmonary medicine · 2020Article
- The study of automatic machine learning base on radiomics of non-focus area in the first chest CT of different clinical types of COVID-19 pneumonia.Scientific reports · 2020Article
- Interstitial Pneumonia with Autoimmune Features.Annals of the American Thoracic Society · 2019Review
- Interstitial Pneumonia With Autoimmune Features (IPAF).Frontiers in medicine · 2019Review
- Mycophenolate therapy in interstitial pneumonia with autoimmune features: a cohort study.Therapeutics and clinical risk management · 2018Article
- Article
- Interstitial Pneumonia with Autoimmune Features: Overview of proposed criteria and recent cohort characterization.Clinical pulmonary medicine · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
context- Patients with idiopathic interstitial pneumonia may display evidence of autoimmunity without meeting criteria for a defined connective tissue disease. A recent European Respiratory Society/American Thoracic Society statement proposed research criteria for interstitial pneumonia with autoimmune features (IPAF), which includes findings from the clinical, serologic, and morphologic domains.
objectives- To investigate the importance of histopathologic criteria within the morphologic domain and to report our methodology for identifying these features.
design- Patients with idiopathic interstitial pneumonia at the University of Chicago who underwent surgical lung biopsy or lung transplantation were assessed for IPAF histopathologic features, using the initial pathology interpretation in the electronic records. A focused rereview of available slides by a pulmonary pathologist was then performed for patients who failed to meet IPAF criteria on initial pathology assessment.
results- Of 422 patients with idiopathic interstitial pneumonia, 176 (41.7%) underwent surgical lung biopsy or lung transplant. Forty-six of those 176 patients (26.1%) met IPAF criteria by initial pathology interpretation and a positive clinical or serologic feature. Of the remaining 130 patients, 73 (56.2%) met either the clinical or serologic domains without meeting the morphologic domain, whereas 36 (27.7%) had slides available for pathology rereview. This rereview demonstrated nonspecific interstitial pneumonia in 8 of 36 patients (22.2%) and lymphoplasmacytic infiltrates in 6 of 36 patients (16.7%), resulting in an additional 7 of 36 patients (19.4%) with idiopathic interstitial pneumonia that met the IPAF criteria. In IPAF, pulmonary vasculopathy was the most prevalent finding (45 of 84; 53.6%) and predicted increased mortality (hazard ratio, 2.5; P = .04).
conclusions- Using a methodological approach to identifying IPAF pathology, we demonstrate a significant increase in the number of patients meeting IPAF criteria because of focused pathologic review and highlight the prognostic value of the IPAF pathologic findings.
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