ArticleArchives of pathology & laboratory medicine2017
Hippocampal Sclerosis in Older Patients: Practical Examples and Guidance With a Focus on Cerebral Age-Related TDP-43 With Sclerosis.
Article in Archives of pathology & laboratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- The mechanisms underlying TDP-43-associated neurodegeneration in Alzheimer's disease and related dementias.Molecular psychiatry · 2025Review
- MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults.JAMA network open · 2025Article
- Cognitive outcomes of deep brain stimulation depend on age and hippocampal connectivity in Parkinson's and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- TDP-43-proteinopathy at the crossroads of tauopathy: on copathology and current and prospective biomarkers.Frontiers in cellular neuroscience · 2025Review
- Decoding TDP-43: the molecular chameleon of neurodegenerative diseases.Acta neuropathologica communications · 2024Review
- Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS.Journal of neuropathology and experimental neurology · 2024Article
- Brain Banking in Dementia Studies.Methods in molecular biology (Clifton, N.J.) · 2024Review
- In severe ADNC, hippocampi with comorbid LATE-NC and hippocampal sclerosis have substantially more astrocytosis than those with LATE-NC or hippocampal sclerosis alone.Journal of neuropathology and experimental neurology · 2023Article
- Performance of a condensed protocol to assess limbic-predominant age-related TDP-43 encephalopathy neuropathologic change.Journal of neuropathology and experimental neurology · 2023Article
- The Role of TDP-43 in Neurodegenerative Disease.Molecular neurobiology · 2022Review
- Neuropathologic Correlates of Human Cortical Proteins in Alzheimer Disease and Related Dementias.Neurology · 2022Article
- Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Cognitive Impairment in Older Adults and Therapeutic Strategies.Pharmacological reviews · 2021Review
- TDP-43 proteinopathies: a new wave of neurodegenerative diseases.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- The neuropathological diagnosis of Alzheimer's disease.Molecular neurodegeneration · 2019Review
- Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy.Laboratory investigation; a journal of technical methods and pathology · 2019Review
- Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.Brain : a journal of neurology · 2019Article
- TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.Neurobiology of disease · 2019Article
- Hippocampal Sclerosis, Argyrophilic Grain Disease, and Primary Age-Related Tauopathy.Continuum (Minneapolis, Minn.) · 2019Review
- Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study.Acta neuropathologica · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
context- Autopsy studies of the older population (≥65 years of age), and particularly of the "oldest-old" (≥85 years of age), have identified a significant proportion (∼20%) of cognitively impaired patients in which hippocampal sclerosis is the major substrate of an amnestic syndrome. Hippocampal sclerosis may also be comorbid with frontotemporal lobar degeneration, Alzheimer disease, and Lewy body disease. Until recently, the terms hippocampal sclerosis of aging or hippocampal sclerosis dementia were applied in this context. Recent discoveries have prompted a conceptual expansion of hippocampal sclerosis of aging because (1) cellular inclusions of TAR DNA-binding protein 43 kDa (TDP-43) are frequent; (2) TDP-43 pathology may be found outside hippocampus; and (3) brain arteriolosclerosis is a common, possibly pathogenic, component.
objective- To aid pathologists with recent recommendations for diagnoses of common neuropathologies in older persons, particularly hippocampal sclerosis, and highlight the recent shift in diagnostic terminology from HS-aging to cerebral age-related TDP-43 with sclerosis (CARTS). DATA SOURCES: - Peer-reviewed literature and 5 autopsy examples that illustrate common age-related neuropathologies, including CARTS, and emphasize the importance of distinguishing CARTS from late-onset frontotemporal lobar degeneration with TDP-43 pathology and from advanced Alzheimer disease with TDP-43 pathology.
conclusions- In advanced old age, the substrates of cognitive impairment are often multifactorial. This article demonstrates common and frequently comorbid neuropathologic substrates of cognitive impairment in the older population, including CARTS, to aid those practicing in this area of pathology.
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