ArticleBiomaterials science2017
Enhanced antibacterial efficacy of nitric oxide releasing thermoplastic polyurethanes with antifouling hydrophilic topcoats.
Article in Biomaterials science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 75 citations in OpenAlex.
- Nitric oxide-releasing dextran surface with enhanced albumin affinity mitigates infection and foreign body reaction.Carbohydrate polymers · 2026Article
- Strategies and applications of antibacterial surface-modified biomaterials.Bioactive materials · 2025Review
- Combating Concomitant Bacterial and Fungal Infections via Codelivery of Nitric Oxide and Fluconazole.ACS applied materials & interfaces · 2025Article
- Surface Engineering for Endothelium-Mimicking Functions to Combat Infection and Thrombosis in Extracorporeal Life Support Technologies.Advanced healthcare materials · 2024Article
- PreventingACS applied bio materials · 2024Article
- Enhanced antibacterial efficacy against antibiotic-resistant bacteria via nitric oxide-releasing ampicillin polymer substrates.Journal of colloid and interface science · 2024Article
- Antibacterial gas therapy: Strategies, advances, and prospects.Bioactive materials · 2023Review
- Recent Strategies and Future Recommendations for the Fabrication of Antimicrobial, Antibiofilm, and Antibiofouling Biomaterials.International journal of nanomedicine · 2023Review
- Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg-Ca-Zn-Ag alloy to inhibit bacterial infection and promote bone regeneration.Bioactive materials · 2022Article
- Bio-inspired hemocompatible surface modifications for biomedical applications.Progress in materials science · 2022Article
- Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials.ACS materials Au · 2022Review
- Smartphone compatible nitric oxide releasing insert to prevent catheter-associated infections.Journal of controlled release : official journal of the Controlled Release Society · 2022Article
- Long-Term Storage Stability and Nitric Oxide Release Behavior of (ACS applied materials & interfaces · 2022Article
- Prevention of medical device infections via multi-action nitric oxide and chlorhexidine diacetate releasing medical grade silicone biointerfaces.Journal of biomedical materials research. Part A · 2022Article
- Antimicrobial Nitric Oxide-Releasing Electrospun Dressings for Wound Healing Applications.ACS materials Au · 2022Article
- Improved Polymer Hemocompatibility for Blood-Contacting Applications viaACS applied materials & interfaces · 2022Article
- Recent Developments in Nitric Oxide Donors and Delivery for Antimicrobial and Anti-Biofilm Applications.Molecules (Basel, Switzerland) · 2022Review
- Surface-Catalyzed Nitric Oxide Release via a Metal Organic Framework Enhances Antibacterial Surface Effects.ACS applied materials & interfaces · 2021Article
- Development of Novel Amphotericin B-Immobilized Nitric Oxide-Releasing Platform for the Prevention of Broad-Spectrum Infections and Thrombosis.ACS applied materials & interfaces · 2021Article
- Combination strategies for antithrombotic biomaterials: an emerging trend towards hemocompatibility.Biomaterials science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Surface fouling is one of the leading causes of infection associated with implants, stents, catheters, and other medical devices. The surface chemistry of medical device coatings is important in controlling and/or preventing fouling. In this study, we have shown that a combination of nitric oxide releasing hydrophobic polymer with a hydrophilic polymer topcoat can significantly reduce protein attachment and subsequently reduce bacterial adhesion as a result of the synergistic effect. Nitric oxide (NO) is a well-known potent antibacterial agent due to its adverse reactions on microbial cell components. Owing to the surface chemistry of hydrophilic polymers, they are suitable as antifouling topcoats. In this study, four biomedical grade polymers were compared for protein adhesion and NO-release behavior: CarboSil 2080A, silicone rubber, SP60D60, and SG80A. SP60D60 was found to resist protein adsorption up to 80% when compared to the other polymers while CarboSil 2080A maintained a steady NO flux even after 24 hours (∼0.50 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.