ReviewJournal of clinical hypertension (Greenwich, Conn.)2017
Calcium supplementation and cardiovascular risk: A rising concern.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Medication for bone loss in female patients with anorexia nervosa: a systematic review and management algorithm.Eating and weight disorders : EWD · 2025Pooled it
- Exploring the Potential Benefits of Natural Calcium-Rich Mineral Waters for Health and Wellness: A Systematic Review.Nutrients · 2023Pooled it
- Effects of calcium supplementation on changes in the IL2, IL4, IL6, IL10 axes and oxidative stress in pregnant women at risk for pre-eclampsia.BMC pregnancy and childbirth · 2024Trial
- The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: A randomized placebo-controlled study.Pregnancy hypertension · 2021Trial
- Article
- Calcium and vitamin D supplementation impact on survival in patients with moderate concomitant aortic and mitral valve disease.Cardiovascular diagnosis and therapy · 2025Article
- The potential protective role of vitamin D and calcium supplements in reducing cardiovascular disease risk among elderly patients with osteopenia.Irish journal of medical science · 2024Article
- Beyond the Coagulation Cascade: Vitamin K and Its Multifaceted Impact on Human and Domesticated Animal Health.Current issues in molecular biology · 2024Review
- Objective Methods to Assess Aorto-Iliac Calcifications: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Contribution of direct-drinking water to calcium and magnesium and the influence on the height in school-age children.Frontiers in nutrition · 2024Article
- Article
- Re-evaluation of calcium carbonate (E 170) as a food additive in foods for infants below 16 weeks of age and follow-up of its re-evaluation as food additive for uses in foods for all population groups.EFSA journal. European Food Safety Authority · 2023Article
- Association of dietary calcium with mortality from all causes, cardiovascular disease and cancer in people with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Bio-Activated PEEK: Promising Platforms for Improving Osteogenesis through Modulating Macrophage Polarization.Bioengineering (Basel, Switzerland) · 2022Review
- Quality of Calcium Food Supplements: Evaluation Compared to Manufacturers' Declarations.Molecules (Basel, Switzerland) · 2022Article
- Association between serum calcium level and in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study.Scientific reports · 2022Article
- Osteoporosis Prevention and Treatment: The Risk of Comorbid Cardiovascular Events in Postmenopausal Women.Cureus · 2022Review
- Analysis of Dietary Supplement Use and Influencing Factors in the Mongolian Population.BioMed research international · 2022Article
- Associations between bone mineral density and coronary artery calcification: a systematic review and meta-analysis.Therapeutic advances in chronic disease · 2022Article
- Physical Fitness and Dietary Intake Improve Mental Health in Chinese Adolescence Aged 12-13.Frontiers in integrative neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past decade, the number of individuals taking calcium supplementation worldwide has been on the rise, especially with the emergence of new pharmaceutical companies specialized in the marketing of dietary supplements; with calcium supplementation being their main business axis. This is mostly because of the established role of calcium in the prevention and treatment of osteoporosis and, to a lesser extent, its role in the prevention of fractures. Recently, a rising body of evidence on the adverse effect of calcium supplementation on nonskeletal, especially cardiovascular, health has been a cause for concern. In fact, a significant number of studies have reported an association between calcium supplementation and adverse cardiovascular events, even though high dietary calcium intake was shown to have a protective effect. The mechanism by which calcium supplementation could cause a cardiovascular event was still unclear until a recent study published in the Journal of the American Heart Association. Combining this recent finding with available data associating calcium supplementation with cardiovascular mortality and all-cause mortality, we call on the need for an evidence-based approach to calcium supplementation, while stressing on the safety of dietary calcium intake over the former on cardiovascular health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.