Evidence map›Paper›PMID 28466437›Full record

ReviewCurrent oncology reports2017

Role of SOX11 and Genetic Events Cooperating with Cyclin D1 in Mantle Cell Lymphoma.

Sílvia Beà, Virginia Amador

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. The pathologic diagnosis of mantle cell lymphoma.Histology and histopathology · 2021
    Review
  6. Article
  7. Review
  8. Review
  9. Highly sensitive and specificHaematologica · 2020
    Article
  10. Article
  11. Blood · 2019
    Article
  12. SOX11: friend or foe in tumor prevention and carcinogenesis?Therapeutic advances in medical oncology · 2019
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sílvia BeàInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBER de Cáncer, C/Rosselló 149-153, 08036, Barcelona, Spain.
Virginia AmadorInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBER de Cáncer, C/Rosselló 149-153, 08036, Barcelona, Spain. vamador@clinic.ub.es.
Centro de Investigación Biomédica en Red · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm, incurable with current therapies. The t(11;14)(q13;q32) involving cyclin D1 is considered the first oncogenic hit found in virtually all MCLs. However, additional secondary genomic alterations are essential for complete transformation. MCLs are genetically very unstable with several genetic alterations associated with its high proliferative behavior involving several oncogenic pathways. Furthermore, SOX11 is overexpressed in the majority of conventional MCLs (cMCL), including cyclin D1-negative cases, but absent in non-nodal leukemic MCL with indolent clinical behavior (nnMCL). Recent data have revealed the potential oncogenic role of SOX11 in MCL biology, highlighting its implication in tumor aggressiveness and progression. This review addresses the implication of SOX11 overexpression and frequent genetic lesions, cooperating with cyclin D1 underlying the pathogenesis of this aggressive disease.

Indexed as

Biomarkers, TumorCarcinogenesisCyclin D1HumansImmunohistochemistryLymphoma, Mantle-CellSOXC Transcription FactorsBiomarkers, TumorCCND1 protein, humanCyclin D1SOX11 protein, humanSOXC Transcription FactorsAngiogenesisCyclin D1Genomic alterationsMantle cell lymphomaProliferationSOX11

Identifiers

PMID28466437
OpenAlexW2610360477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.