ReviewRheumatology international2017
Women with silicone breast implants and autoimmune inflammatory syndrome induced by adjuvants: description of three patients and a critical review of the literature.
Review in Rheumatology international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Comprehensive Systematic Review of Breast Implant Illness: Symptoms, Management, and Long-Term Outcomes.Aesthetic plastic surgery · 2025Pooled it
- Incidence of autoimmune disease after hernia surgery with a mesh implant: national retrospective cohort study.The British journal of surgery · 2026Article
- Article
- Adjuvant-induced autoimmune syndrome (ASIA syndrome) and the role of sonography in its diagnosis: a case-based review.Rheumatology international · 2025Review
- Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) After Polypropylene Mesh Implantation - Protocol of a Pilot Study for Diagnostics and Treatment.Journal of abdominal wall surgery : JAWS · 2025Article
- Clinical Characteristics of ASIA Syndrome in Patients with Silicone Breast Implants: A Scoping Review.World journal of plastic surgery · 2025Review
- Article
- Patient-reported systemic symptoms in women with silicone breast implants: a descriptive cohort study.BMJ open · 2022Observational
- A Practical Guide to Managing Patients With Systemic Symptoms and Breast Implants.Aesthetic surgery journal · 2022Article
- Classification for Staging and Managing Patients with Biopolymer-induced Human Adjuvant Disease.Plastic and reconstructive surgery. Global open · 2022Article
- Self-Reported Health Complaints in Women Undergoing Explantation of Breast Implants.Aesthetic surgery journal · 2022Article
- Pulmonary fibrosis and embolism secondary to silicon implant leak.BMJ case reports · 2019Article
- Silicone breast implants and depression, fibromyalgia and chronic fatigue syndrome in a rheumatology clinic population.Clinical rheumatology · 2019Article
- Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), medical treatment of severe systemic compromise: case report.Colombia medica (Cali, Colombia)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silicone has been widely used in the manufacture of medical implants. It is well tolerated in most cases. However, in this paper we report the cases of three women who developed autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), namely with silicone breast implants. The symptoms in these cases include arthralgia, arthritis, myalgia, sleep disturbances, the appearance of autoantibodies, miscarriage, Raynaud's phenomenon, and involvement of autoimmune diseases (scleroderma and undifferentiated connective tissue diseases). In one patient, breast implants were removed, but no improvement was seen after the removal. The remaining two patients received the updated information about their condition, and they decided not to remove the implants. In conclusion, earlier reports that silicone is biologically relatively inert have recently been challenged with the description of ASIA syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.