ReviewNeuroscience bulletin2018
Cortical Representation of Pain and Touch: Evidence from Combined Functional Neuroimaging and Electrophysiology in Non-human Primates.
Review in Neuroscience bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- A Multiregional Functional Ultrasound Dataset of Brain Responses to Innocuous and Noxious Mechanical Stimulation in Awake Mice.Neuroscience bulletin · 2026Article
- A Personalized Predictor of Motor Imagery Ability Based on Multi-frequency EEG Features.Neuroscience bulletin · 2025Article
- Distinct functional cerebral hypersensitivity networks during incisional and inflammatory pain in rats.Current research in neurobiology · 2025Article
- Modulating nociception networks: the impact of low-intensity focused ultrasound on thalamocortical connectivity.Brain communications · 2025Article
- The Hedonic Experience Associated with a Gentle Touch Is Preserved in Women with Fibromyalgia.Journal of clinical medicine · 2024Article
- Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex.Nature communications · 2022Article
- Limits of decoding mental states with fMRI.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- The Modulatory Effect of Motor Cortex Astrocytes on Diabetic Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice.Neuroscience bulletin · 2021Article
- Article
- Enlightening the frontiers of neurogastroenterology through optogenetics.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Pharmacologic Modulation of Noxious Stimulus-evoked Brain Activation in Cynomolgus Macaques Observed with Functional Neuroimaging.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neuromodulation of sensory networks in monkey brain by focused ultrasound with MRI guidance and detection.Scientific reports · 2018Article
- Recent Progress in Understanding the Mechanisms of Pain and Itch: the Second Special Issue.Neuroscience bulletin · 2018Article
- Gaps in Understanding Mechanism and Lack of Treatments: Potential Use of a Nonhuman Primate Model of Oxaliplatin-Induced Neuropathic Pain.Pain research & management · 2018Review
- Differential dose responses of transcranial focused ultrasound at brain regions indicate causal interactions.Brain stimulationArticle
- Disrupting nociceptive information processing flow through transcranial focused ultrasound neuromodulation of thalamic nuclei.Brain stimulationArticle
- Bidirectional and state-dependent modulation of brain activity by transcranial focused ultrasound in non-human primates.Brain stimulationArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Human functional MRI studies in acute and various chronic pain conditions have revolutionized how we view pain, and have led to a new theory that complex multi-dimensional pain experience (sensory-discriminative, affective/motivational, and cognitive) is represented by concurrent activity in widely-distributed brain regions (termed a network or pain matrix). Despite these breakthrough discoveries, the specific functions proposed for these regions remain elusive, because detailed electrophysiological characterizations of these regions in the primate brain are lacking. To fill in this knowledge gap, we have studied the cortical areas around the central and lateral sulci of the non-human primate brain with combined submillimeter resolution functional imaging (optical imaging and fMRI) and intracranial electrophysiological recording. In this mini-review, I summarize and present data showing that the cortical circuitry engaged in nociceptive processing is much more complex than previously recognized. Electrophysiological evidence supports the engagement of a distinct nociceptive-processing network within SI (i.e., areas 3a, 3b, 1 and 2), SII, and other areas along the lateral sulcus. Deafferentation caused by spinal cord injury profoundly alters the relationships between fMRI and electrophysiological signals. This finding has significant implications for using fMRI to study chronic pain conditions involving deafferentation in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.