ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Bone material strength index as measured by impact microindentation is low in patients with fractures irrespective of fracture site.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis.Pituitary · 2022Pooled it
- Added Value of Impact Microindentation in the Evaluation of Bone Fragility: A Systematic Review of the Literature.Frontiers in endocrinology · 2020Pooled it
- A critique on associations between bone material strength index and FRAX scores.Journal of bone and mineral metabolism · 2025Article
- Associations between bone material strength index and FRAX scores.Journal of bone and mineral metabolism · 2025Article
- Utility and Limitations of TALLYHO/JngJ as a Model for Type 2 Diabetes-Induced Bone Disease.JBMR plus · 2023Article
- For older individuals there is greater variance in low mean Bone Material Strength Index values obtained with the OsteoProbe.Bone reports · 2023Article
- Mean Bone Material Strength Index Values for Women are Lower Than Those for Men: Data from a Single Geographical Location.Calcified tissue international · 2023Article
- Safety Outcomes of Impact Microindentation: A Prospective Observational Study in the Netherlands.JBMR plus · 2023Article
- Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study.Calcified tissue international · 2023Article
- Management of fracture risk in CKD-traditional and novel approaches.Clinical kidney journal · 2023Review
- Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Bone Material Strength Index as Measured by Impact Microindentation is Low in Patients with Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2021Article
- Treatments of osteoporosis increase bone material strength index in patients with low bone mass.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Normative Data for Impact Microindentation for Australian Men: Cross-Sectional Data From the Geelong Osteoporosis Study.JBMR plus · 2020Article
- Bone tissue quality in patients with monoclonal gammopathy of uncertain significance.Journal of bone and mineral metabolism · 2020Article
- Trabecular bone score and quantitative ultrasound measurements in the assessment of bone health in breast cancer survivors assuming aromatase inhibitors.Journal of endocrinological investigation · 2019Article
- Fracture prediction, imaging and screening in osteoporosis.Nature reviews. Endocrinology · 2019Review
- Feasibility and tolerability of bone impact microindentation testing: a cross-sectional, population-based study in Australia.BMJ open · 2018Article
- Clinical measurements of bone tissue mechanical behavior using reference point indentation.Clinical reviews in bone and mineral metabolism · 2018Article
- Mechanical Characterization of Bone: State of the Art in Experimental Approaches-What Types of Experiments Do People Do and How Does One Interpret the Results?Current osteoporosis reports · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
We evaluated the relationship between bone material strength index (BMSi) and fragility fractures, including vertebral fractures. Our data showed that BMSi is low in all fracture patients with low bone mass, independently of whether patients sustained a vertebral or a non-vertebral fracture.
introductionImpact microindentation (IMI) is a new technique for the measurement of tissue level properties of cortical bone in vivo. Previous studies showed an association between BMSi and non-vertebral fractures, but an association with vertebral fractures is still being debated. The objective of this paper was to evaluate the relationship between BMSi and different types of fragility fractures, including vertebral fractures.
methodsIn this cross-sectional study, we measured BMSi in patients of both sexes with different types of fragility fractures and low bone mass with the IMI method using the Osteoprobe®. Vertebral fractures were diagnosed and graded on lateral spine radiographs.
resultsA total of 132 patients were included in the study, of whom 101 patients (65 women) had sustained a low energy fracture and 31 (mean age 57.7 ± 9.9 years) had no history or radiological evidence for a fracture. Of the fracture patients, 53 (mean age 62.8 ± 8.3 years) had only non-vertebral fractures (VF-/Fx+), 34 (mean age 62.8 ± 9.9 years) had vertebral and non-vertebral fractures (VF+/Fx+), and 14 (mean age 64.7 ± 9.3 years) had only vertebral fractures (VF+/Fx-). BMSi values, adjusted for age and BMD, were similar for all three groups of fracture patients (78.9 ± 0.7, 78.3 ± 0.9, and 78.4 ± 1.4, respectively; p = 0.866). BMSi values were not associated with number or severity of vertebral fractures.
conclusionOur data demonstrate that BMSi is low in fracture patients with low bone mass, irrespective of whether they sustained a vertebral fracture or a non-vertebral fracture.
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