Evidence map›Paper›PMID 28466013›Full record

ReviewBioMed research international2017

Do miRNAs Play a Role in Fetal Growth Restriction? A Fresh Look to a Busy Corner.

Benito Chiofalo, Antonio Simone Laganà, Alberto Vaiarelli, Valentina Lucia La Rosa, Diego Rossetti, Vittorio Palmara, Gaetano Valenti, Agnese Maria Chiara Rapisarda, Roberta Granese, Fabrizio Sapia and 2 more

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Benito ChiofaloUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Antonio Simone LaganàUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.ORCID 0000-0003-1543-2802
Alberto VaiarelliUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.ORCID 0000-0002-0873-3925
Valentina Lucia La RosaUnit of Psychodiagnostics and Clinical Psychology, University of Catania, Catania, Italy.
Diego RossettiDepartment of Maternal and Child Health, Gavardo Hospital, Brescia, Italy.
Vittorio PalmaraUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Gaetano ValentiDepartment of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.
Agnese Maria Chiara RapisardaDepartment of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.
Roberta GraneseUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.ORCID 0000-0003-0318-9390
Fabrizio SapiaDepartment of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.
Onofrio TrioloUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Salvatore Giovanni VitaleUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.ORCID 0000-0001-6871-6097
University of Messina · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Placenta is the crucial organ for embryo and fetus development and plays a critical role in the development of fetal growth restriction (FGR). There are increasing evidences on the role of microRNAs (miRNAs) in a variety of pregnancy-related complications such as preeclampsia and FGR. More than 1880 miRNAs have been reported in humans and most of them are expressed in placenta. In this paper, we aimed to review the current evidence about the topic. According to retrieved data, controversial results about placental expression of miRNAs could be due (at least in part) to the different experimental methods used by different groups. Despite the fact that several authors have demonstrated a relatively easy and feasible detection of some miRNAs in maternal whole peripheral blood, costs of these tests should be reduced in order to increase cohorts and have stronger evidence. In this regard, we take the opportunity to solicit future studies on large cohort and adequate statistical power, in order to identify a panel of biomarkers on maternal peripheral blood for early diagnosis of FGR.

Indexed as

FemaleFetal Growth RetardationGene Expression RegulationHumansMicroRNAsPlacentaPre-EclampsiaPregnancyPregnancy ComplicationsMicroRNAs

Identifiers

PMID28466013
PMCPMC5390605
OpenAlexW2598465035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.