Evidence map›Paper›PMID 28465805›Full record

ReviewElectronic physician2017

Pathogenesis and treatment of post-operative cognitive dysfunction.

Maria Pappa, Nikolaos Theodosiadis, Andreas Tsounis, Pavlos Sarafis

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Electronic physician, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05378659 (Neuroinflammation and Alzheimer's Pathology in Post-operative Cognitive Dysfunction), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05378659 unknown statusnot on this mapstarted 2021, after this paper: background citation

Neuroinflammation and Alzheimer's Pathology in Post-operative Cognitive Dysfunction: A Pilot Study

TypeobservationalSponsorUniversity of Tennessee Graduate School of MedicineRan2021 to 2022Enrolled120ConditionsPost-Operative Confusion, Neuroinflammatory Response, Alzheimer DiseaseArmsMontreal Cognitive Assessment, Stroop Test, 4AT Delirium, Grooved Pegboard, NACC Cognitive Battery
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  12. Recent advances in the management of chronic ankle instability.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Postoperative cognitive dysfunction-current research progress.Frontiers in behavioral neuroscience · 2024
    Review
  17. Article
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  19. The effect of melatonin on cognitive functions following coronary artery bypass grafting: A triple-blind randomized-controlled trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Maria Pappa414 Military Hospital of Special Diseases, Athens, Greece.
Nikolaos Theodosiadis401 Military Hospital of Athens, Athens, Greece.
Andreas TsounisCenters for the Prevention of Addictions and Promoting Psychosocial Health of Municipality of Thessaloniki, Thessaloniki, Greece.
Pavlos SarafisNursing Department, Cyprus University of Technology, Limassol, Cyprus.
401 General Military Hospital of Athens · GRCyprus University of Technology · CYHellenic Agency for Local Development and Local Government · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive disorders common in the post-operative period, are the post-operative delirium (POD) and the post-operative cognitive dysfunction (POCD). The Diagnostic and Statistical Manual of Mental Disorders (DSM) does not mention POCD as a separate disease entity, and thus little is known about the pathogenesis of this disorder. The aim of this study was to review, detect and highlight the most important data cited, regarding pathogenesis mechanisms and treatment of the post-operative cognitive dysfunction (POCD). The study was carried out from March 2015 to June 2015. Literature review was achieved by searching a number of bibliographic databases including PubMed, Google Scholar and SCOPUS, surveying published articles from 1955 to 2014. As far as the selection criteria, the material consists of scientific articles published mainly over the last fifteen years, while material published before 2000 was selected because it was considered to be important. This review showed that deficits are observed in one or more discrete areas of the patient's mental state, such as attention, concentration, memory, psychomotor speed and more. This condition is usually developed over a period of more than a week or month after surgery and is more common in elderly patients. Mechanisms that have been proposed to explain this phenomenon are hyperventilation, hypotension, cerebral microemboli and inflammatory mechanisms. Its differential diagnosis will be made mainly from delirium. POCD treatment will first include the exclusion of any other serious diseases that can cause organic psychosyndrome and then focus on the actual symptoms.

Indexed as

Memory deteriorationPathogenesisPost-operative cognitive dysfunctionPost-operative mental disorder

Identifiers

PMID28465805
PMCPMC5410904
OpenAlexW2594039775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.